Nature Cell Biology 7, 777 - 778 (2005)
doi:10.1038/ncb0805-777
Rac and cell migration: CDM proteins integrate signalsHenry R. Bourne
Henry R. Bourne is in the Departments of Cellular and Molecular Pharmacology and Medicine, and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0450, USA. bourne@cmp.ucsf.edu
Cell migration requires that Rac GTPases promote formation of actin polymers at the cell's leading edge. An activator of Rac, DOCK180, accomplishes this localization by using its DHR-1 domain to bind phosphatidylinositol-3,4,5-trisphosphate at the membrane.
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