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Nature Cell Biology 7, 777 - 778 (2005)
doi:10.1038/ncb0805-777
Rac and cell migration: CDM proteins integrate signals
Henry R. Bourne1
- Henry R. Bourne is in the Departments of Cellular and Molecular Pharmacology and Medicine, and the Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0450, USA. e-mail: bourne@cmp.ucsf.edu
Abstract
Cell migration requires that Rac GTPases promote formation of actin polymers at the cell's leading edge. An activator of Rac, DOCK180, accomplishes this localization by using its DHR-1 domain to bind phosphatidylinositol-3,4,5-trisphosphate at the membrane.
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