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Nature Cell Biology 7, 773 - 774 (2005)
doi:10.1038/ncb0805-773
Substrate specificity: PI(3)K
has it both ways
Jonathan M. Backer1
- Jonathan M. Backer is in the Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, 10461, USA. e-mail: backer@aecom.yu.edu
Abstract
Phosphoinositide 3-kinases (PI(3)Ks) are mainly known for their lipid kinase activity in various cellular functions; however, PI(3)Ks also have protein kinase activity. Non-muscle tropomyosin has been identified as a novel protein target for PI(3)K
. Phosphorylation of tropomyosin is required for 
-adrenergic receptor internalization, providing new insight into PI(3)K function during clathrin-mediated endocytosis.
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RESEARCH
Protein kinase activity of phosphoinositide 3-kinase regulates β-adrenergic receptor endocytosisNature Cell Biology Article (01 Aug 2005)
