Nature Cell Biology 7, 758 - 765 (2005)
doi:10.1038/ncb0805-758
Ubiquitin signalling in the NF- B pathwayZhijian J. Chen
Zhijian J. Chen is in the Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9148, USA. zhijian.chen@utsouthwestern.edu
The transcription factor NF- B (nuclear factor kappa enhancer binding protein) controls many processes, including immunity, inflammation and apoptosis. Ubiquitination regulates at least three steps in the NF-B pathway: degradation of IB (inhibitor of NF-B), processing of NF-B precursors, and activation of the IB kinase (IKK). Recent studies have revealed several enzymes involved in the ubiquitination and deubiquitination of signalling proteins that mediate IKK activation through a degradation-independent mechanism.
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