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Nature Cell Biology 7, 648–650 (1 July 2005) | doi:10.1038/ncb0705-648
Nbs1 moving up in the world
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Abstract
Nbs1 was identified in 1998, as the protein product of the gene that is mutated in Nijmegen breakage syndrome (NBS) patients, a syndrome characterized by radiation sensitivity and premature ageing. In cells, Nbs1 is found in complex with the exonuclease Mre11 and with Rad50, a protein related to the structural subunits of cohesins, which hold sister chromatids together.
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