Moving forward with cell migration - p639

doi:10.1038/ncb0705-639a

Full Text - Moving forward with cell migration | PDF (86 KB) - Moving forward with cell migration

Databases in peril - p639

doi:10.1038/ncb0705-639b

Full Text - Databases in peril | PDF (86 KB) - Databases in peril

Viral entry: a detour through multivesicular bodies - pp641 - 642

Pradeep Uchil & Walther Mothes

doi:10.1038/ncb0705-641

Many viruses and toxins enter the cytoplasm of cells by crossing endosomal membranes. New evidence now suggests that if entry occurs through multivesicular bodies, then they are first delivered into intraluminal vesicles before their final transfer into the cytoplasm via the 'back-fusion' of these vesicles.

Full Text - Viral entry: a detour through multivesicular bodies | PDF (148 KB) - Viral entry: a detour through multivesicular bodies

RNAi and the P-body connection - pp643 - 644

John J. Rossi

doi:10.1038/ncb0705-643

Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now connects the RNA interference machinery with P-body formation.

Full Text - RNAi and the P-body connection | PDF (229 KB) - RNAi and the P-body connection

A central role for S-nitrosylation in apoptosis - pp645 - 646

Moran Benhar & Jonathan S. Stamler

doi:10.1038/ncb0705-645

New work reveals a key signal transduction pathway through which nitric oxide (NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin-mediated degradation of nuclear target proteins.

Full Text - A central role for S-nitrosylation in apoptosis | PDF (140 KB) - A central role for S-nitrosylation in apoptosis

Protein quality control: knowing when to fold - p647

Sowmya Swaminathan

doi:10.1038/ncb0705-647

Full Text - Protein quality control: knowing when to fold | PDF (227 KB) - Protein quality control: knowing when to fold

Nbs1 moving up in the world - pp648 - 650

Elena S. Stavridi & Thanos D. Halazonetis

doi:10.1038/ncb0705-648

The Nbs1 protein participates in the cell-cycle checkpoint response to DNA double-strand breaks (DSBs), but its precise mode of action — especially in relation to the checkpoint kinase Atm — has been debated. New mouse models suggest that Nbs1 is required for activation of Atm in response to DNA DSBs and that it also functions in an amplification loop with Atm that allows even a small number of DNA DSBs to mount a potent checkpoint response.

Full Text - Nbs1 moving up in the world | PDF (165 KB) - Nbs1 moving up in the world

Huntingtin and the vicious circle - p650

Jack Horne

doi:10.1038/ncb0705-650

Full Text - Huntingtin and the vicious circle | PDF (102 KB) - Huntingtin and the vicious circle

Domains galore - p651

Luis Serrano reviews Modular Protein Domains by G. Cesareni, M. Gimona, M. Sudol & M. Yaffe

doi:10.1038/ncb0705-651

Full Text - Domains galore | PDF (90 KB) - Domains galore

Endosome-to-cytosol transport of viral nucleocapsids - pp653 - 664

Isabelle Le Blanc, Pierre-Philippe Luyet, Véronique Pons, Charles Ferguson, Neil Emans, Anne Petiot, Nathalie Mayran, Nicolas Demaurex, Julien Fauré, Rémy Sadoul, Robert G. Parton & J. Gruenberg

doi:10.1038/ncb1269

Abstract - | Full Text - Endosome-to-cytosol transport of viral nucleocapsids | PDF (2,175 KB) - Endosome-to-cytosol transport of viral nucleocapsids | Supplementary information

See also: News and Views by Uchil & Mothes

S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding - pp665 - 674

Makoto R. Hara, Nishant Agrawal, Sangwon F. Kim, Matthew B. Cascio, Masahiro Fujimuro, Yuji Ozeki, Masaaki Takahashi, Jaime H. Cheah, Stephanie K. Tankou, Lynda D. Hester, Christopher D. Ferris, S. Diane Hayward, Solomon H. Snyder & Akira Sawa

doi:10.1038/ncb1268

Abstract - | Full Text - S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding | PDF (1,257 KB) - S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding | Supplementary information

See also: News and Views by Benhar & Stamler

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models - pp675 - 685

Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig & André Nussenzweig

doi:10.1038/ncb1270

Abstract - | Full Text - Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models | PDF (2,875 KB) - Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models | Supplementary information

See also: News and Views by Stavridi & Halazonetis

NudEL targets dynein to microtubule ends through LIS1 - pp686 - 690

Jun Li, Wei-Lih Lee & John A. Cooper

doi:10.1038/ncb1273

First Paragraph - | Full Text - NudEL targets dynein to microtubule ends through LIS1 | PDF (910 KB) - NudEL targets dynein to microtubule ends through LIS1 | Supplementary information

Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding - pp691 - 697

Andreas Jenny, Jessica Reynolds-Kenneally, Gishnu Das, Micheal Burnett & Marek Mlodzik

doi:10.1038/ncb1271

First Paragraph - | Full Text - Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding | PDF (1,566 KB) - Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding | Supplementary information

The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate - pp698 - 705

Monica Dentice, Amitabha Bandyopadhyay, Balázs Gereben, Isabelle Callebaut, Marcelo A. Christoffolete, Brian W. Kim, Sahar Nissim, Jean-Paul Mornon, Ann Marie Zavacki, Anikó Zeöld, Luciane P. Capelo, Cyntia Curcio-Morelli, Rogério Ribeiro, John W. Harney, Clifford J. Tabin & Antonio C. Bianco

doi:10.1038/ncb1272

First Paragraph - | Full Text - The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate | PDF (1,123 KB) - The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate | Supplementary information

Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation - pp706 - 711

Ling Qi, Margaret A. Strong, Baktiar O. Karim, David L. Huso & Carol W. Greider

doi:10.1038/ncb1276

First Paragraph - | Full Text - Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation | PDF (945 KB) - Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation | Supplementary information

DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion - pp712 - 718

Giulia B. Celli & Titia de Lange

doi:10.1038/ncb1275

First Paragraph - | Full Text - DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion | PDF (1,252 KB) - DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion | Supplementary information

MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies - pp719 - 723

Jidong Liu, Marco Antonio Valencia-Sanchez, Gregory J. Hannon & Roy Parker

doi:10.1038/ncb1274

First Paragraph - | Full Text - MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies | PDF (732 KB) - MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies | Supplementary information

See also: News and Views by Rossi