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Editorials

Moving forward with cell migration p639

doi:10.1038/ncb0705-639a


Databases in peril p639

doi:10.1038/ncb0705-639b


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News and Views

Viral entry: a detour through multivesicular bodies pp641 - 642

Pradeep Uchil & Walther Mothes

doi:10.1038/ncb0705-641

Many viruses and toxins enter the cytoplasm of cells by crossing endosomal membranes. New evidence now suggests that if entry occurs through multivesicular bodies, then they are first delivered into intraluminal vesicles before their final transfer into the cytoplasm via the 'back-fusion' of these vesicles.


RNAi and the P-body connection pp643 - 644

John J. Rossi

doi:10.1038/ncb0705-643

Cytoplasmic processing bodies, also known as P-bodies, concentrate enzymes that are involved in mRNA turnover and sequester mRNAs away from the translational machinery. Strong evidence now connects the RNA interference machinery with P-body formation.


A central role for S-nitrosylation in apoptosis pp645 - 646

Moran Benhar & Jonathan S. Stamler

doi:10.1038/ncb0705-645

New work reveals a key signal transduction pathway through which nitric oxide (NO) regulates apoptosis induced by disparate cellular stresses. Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is S-nitrosylated by NO, which initiates an interaction with the E3 ligase Siah1, leading to nuclear translocation and ubiquitin-mediated degradation of nuclear target proteins.


Protein quality control: knowing when to fold p647

Sowmya Swaminathan

doi:10.1038/ncb0705-647


Nbs1 moving up in the world pp648 - 650

Elena S. Stavridi & Thanos D. Halazonetis

doi:10.1038/ncb0705-648

The Nbs1 protein participates in the cell-cycle checkpoint response to DNA double-strand breaks (DSBs), but its precise mode of action — especially in relation to the checkpoint kinase Atm — has been debated. New mouse models suggest that Nbs1 is required for activation of Atm in response to DNA DSBs and that it also functions in an amplification loop with Atm that allows even a small number of DNA DSBs to mount a potent checkpoint response.


Huntingtin and the vicious circle p650

Jack Horne

doi:10.1038/ncb0705-650


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Book Review

Domains galore p651

Luis Serrano reviews Modular Protein Domains by G. Cesareni, M. Gimona, M. Sudol & M. Yaffe

doi:10.1038/ncb0705-651


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Articles

Endosome-to-cytosol transport of viral nucleocapsids pp653 - 664

Isabelle Le Blanc, Pierre-Philippe Luyet, Véronique Pons, Charles Ferguson, Neil Emans, Anne Petiot, Nathalie Mayran, Nicolas Demaurex, Julien Fauré, Rémy Sadoul, Robert G. Parton & J. Gruenberg

doi:10.1038/ncb1269

See also: News and Views by Uchil & Mothes


S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding pp665 - 674

Makoto R. Hara, Nishant Agrawal, Sangwon F. Kim, Matthew B. Cascio, Masahiro Fujimuro, Yuji Ozeki, Masaaki Takahashi, Jaime H. Cheah, Stephanie K. Tankou, Lynda D. Hester, Christopher D. Ferris, S. Diane Hayward, Solomon H. Snyder & Akira Sawa

doi:10.1038/ncb1268

See also: News and Views by Benhar & Stamler


Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models pp675 - 685

Simone Difilippantonio, Arkady Celeste, Oscar Fernandez-Capetillo, Hua-Tang Chen, Bernardo Reina San Martin, Francois Van Laethem, Yong-Ping Yang, Galina V. Petukhova, Michael Eckhaus, Lionel Feigenbaum, Katia Manova, Michael Kruhlak, R. Daniel Camerini-Otero, Shyam Sharan, Michel Nussenzweig & André Nussenzweig

doi:10.1038/ncb1270

See also: News and Views by Stavridi & Halazonetis


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Letters

NudEL targets dynein to microtubule ends through LIS1 pp686 - 690

Jun Li, Wei-Lih Lee & John A. Cooper

doi:10.1038/ncb1273


Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding pp691 - 697

Andreas Jenny, Jessica Reynolds-Kenneally, Gishnu Das, Micheal Burnett & Marek Mlodzik

doi:10.1038/ncb1271


The Hedgehog-inducible ubiquitin ligase subunit WSB-1 modulates thyroid hormone activation and PTHrP secretion in the developing growth plate pp698 - 705

Monica Dentice, Amitabha Bandyopadhyay, Balázs Gereben, Isabelle Callebaut, Marcelo A. Christoffolete, Brian W. Kim, Sahar Nissim, Jean-Paul Mornon, Ann Marie Zavacki, Anikó Zeöld, Luciane P. Capelo, Cyntia Curcio-Morelli, Rogério Ribeiro, John W. Harney, Clifford J. Tabin & Antonio C. Bianco

doi:10.1038/ncb1272


Telomere fusion to chromosome breaks reduces oncogenic translocations and tumour formation pp706 - 711

Ling Qi, Margaret A. Strong, Baktiar O. Karim, David L. Huso & Carol W. Greider

doi:10.1038/ncb1276



MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies pp719 - 723

Jidong Liu, Marco Antonio Valencia-Sanchez, Gregory J. Hannon & Roy Parker

doi:10.1038/ncb1274

See also: News and Views by Rossi


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