Letter abstract
Nature Cell Biology 7, 691 - 697 (2005)
Published online: 5 June 2005 | doi:10.1038/ncb1271
Diego and Prickle regulate Frizzled planar cell polarity signalling by competing for Dishevelled binding
Andreas Jenny1, Jessica Reynolds-Kenneally1, Gishnu Das1, Micheal Burnett1 & Marek Mlodzik1
Epithelial planar cell polarity (PCP) is evident in the cellular organization of many tissues in vertebrates and invertebrates1, 2, 3, 4, 5. In mammals, PCP signalling governs convergent extension during gastrulation and the organization of a wide variety of structures, including the orientation of body hair and sensory hair cells of the inner ear6, 7. In Drosophila melanogaster, PCP is manifest in adult tissues, including ommatidial arrangement in the compound eye and hair orientation in wing cells1, 2, 4. PCP establishment requires the conserved Frizzled/Dishevelled PCP pathway1, 2, 3, 4, 5. Mutations in PCP-pathway-associated genes cause aberrant orientation of body hair or inner-ear sensory cells in mice6, 7, or misorientation of ommatidia and wing hair in D. melanogaster1, 2, 4. Here we provide mechanistic insight into Frizzled/Dishevelled signalling regulation. We show that the ankyrin-repeat protein Diego binds directly to Dishevelled and promotes Frizzled signalling. Dishevelled can also be bound by the Frizzled PCP antagonist Prickle8. Strikingly, Diego and Prickle compete with one another for Dishevelled binding, thereby modulating Frizzled/Dishevelled activity and ensuring tight control over Frizzled PCP signalling.
- Mount Sinai School of Medicine, Brookdale Department of Molecular, Cellular and Developmental Biology, 1 Gustave L. Levy Place, New York, NY 10029, USA.
Correspondence to: Marek Mlodzik1 e-mail: marek.mlodzik@mssm.edu
MORE ARTICLES LIKE THIS
These links to content published by NPG are automatically generated.
NEWS AND VIEWS
Strabismus comes into focusNature Cell Biology News and Views (01 Jan 2002)
Wnt signalling sees spotsNature Cell Biology News and Views (01 Nov 2002)
See all 5 matches for News And ViewsRESEARCH
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signalingThe EMBO Journal Article (01 Sep 2003)
Prickle and Strabismus form a functional complex to generate a correct axis during planar cell polarity signalingThe EMBO Journal Article (01 Sep 2003)
See all 28 matches for Research
