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Nature Cell Biology 7, 548–550 (1 June 2005) | doi:10.1038/ncb0605-548

A sixth sense for Rab5

Alexander M. van der Bliek

Rab5 is one of the more intensely studied members of the large and diverse family of Rab GTPases. Functional studies indicate that it is a key regulator of early endocytosis, where it is involved in clathrin-coated vesicle formation, fusion between early endosomes, endosomal cargo recruitment and endosomal motility.