Table of contents
June 2005, Volume 7 No 6 pp533-637
About the coverEditorial
In their own words - p533
doi:10.1038/ncb0605-533
Full Text - In their own words | PDF (94 KB) - In their own words
Review
Coupling cell proliferation and development in plants - pp535 - 541
Crisanto Gutierrez
doi:10.1038/ncb0605-535
Abstract - | Full Text - Coupling cell proliferation and development in plants | PDF (363 KB) - Coupling cell proliferation and development in plants
News and Views
Fickle factor foils fat fate - pp543 - 545
Ormond A. MacDougald & Charles F. Burant
doi:10.1038/ncb0605-543
Factors that determine whether precursor cells will differentiate into adipocytes remain poorly understood. A systematic evaluation of gene expression in cells with a continuum of differentiation potentials has confirmed the importance of certain pathways and has identified a novel regulator of brown adipogenesis.
Full Text - Fickle factor foils fat fate | PDF (148 KB) - Fickle factor foils fat fate
Foot in mouth: do focal adhesions disassemble by endocytosis? - pp545 - 547
Keith Burridge
doi:10.1038/ncb0505-545
How cells disassemble their focal adhesions is not well understood. Now, Ezratty et al. have shown that the GTPase dynamin acts after microtubule targeting of focal adhesions to trigger their disassembly. One intriguing possibility is that dynamin might drive disassembly through endocytosis.
Full Text - Foot in mouth: do focal adhesions disassemble by endocytosis? | PDF (291 KB) - Foot in mouth: do focal adhesions disassemble by endocytosis?
See also: Article by Ezratty et al.
A sixth sense for Rab5 - pp548 - 550
Alexander M. van der Bliek
doi:10.1038/ncb0605-548
It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.
Full Text - A sixth sense for Rab5 | PDF (327 KB) - A sixth sense for Rab5
See also: Article by Sato et al.
On the bright side of microarrays - p550
Jack Horne
doi:10.1038/ncb0605-550
Full Text - On the bright side of microarrays | PDF (212 KB) - On the bright side of microarrays
The Crm de la crème of mitosis - pp551 - 552
Paul R. Clarke
doi:10.1038/ncb0605-551
The small GTPase Ran controls nucleocytoplasmic transport and has multiple roles during cell division. A new study has identified the nuclear export factor Crm1 as a mitotic effector of Ran-GTP at kinetochores, where it has a role in microtubule attachment.
Full Text - The Crm de la crème of mitosis | PDF (133 KB) - The Crm de la crème of mitosis
See also: Letter by Arnaoutov et al.
Transcription RINGs in repair - pp553 - 555
Mary Ann Osley
doi:10.1038/ncb0605-553
A recent study has shown that the Ssl1 subunit of the general transcription/DNA repair factor TFIIH contains ubiquitin ligase activity that is dependent on a RING domain. The RING domain is required for transcription of a subset of yeast genes that are involved in DNA damage repair, thus uncovering a novel ubiquitination-associated function for TFIIH in the repair process.
Full Text - Transcription RINGs in repair | PDF (161 KB) - Transcription RINGs in repair
Obituary
Stanley J. Korsmeyer 1950–2005 - p556
Jay L. Hess
doi:10.1038/ncb0605-556
Full Text - Stanley J. Korsmeyer 1950–2005 | PDF (196 KB) - Stanley J. Korsmeyer 1950–2005
Book Review
Talking about their g-g-generation - p557
Nathaniel Comfort reviews Conversations in Genetics: an Oral History of our Intellectual Heritage in Genetics, Vols 1 and 2 by Rochelle Easton Esposito
doi:10.1038/ncb0605-557
Full Text - Talking about their g-g-generation | PDF (92 KB) - Talking about their g-g-generation
Articles
Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit - pp559 - 569
Miyuki Sato, Ken Sato, Paul Fonarev, Chih-Jen Huang, Willisa Liou & Barth D. Grant
doi:10.1038/ncb1261
Abstract - | Full Text - Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit | PDF (1,607 KB) - Caenorhabditis elegans RME-6 is a novel regulator of RAB-5 at the clathrin-coated pit | Supplementary information
See also: News and Views by van der Bliek
CtBP3/BARS drives membrane fission in dynamin-independent transport pathways - pp570 - 580
Matteo Bonazzi, Stefania Spanò, Gabriele Turacchio, Claudia Cericola, Carmen Valente, Antonino Colanzi, Hee Seok Kweon, Victor W. Hsu, Elena V. Polishchuck, Roman S. Polishchuck, Michele Sallese, Teodoro Pulvirenti, Daniela Corda & Alberto Luini
doi:10.1038/ncb1260
Abstract - | Full Text - CtBP3/BARS drives membrane fission in dynamin-independent transport pathways | PDF (1,771 KB) - CtBP3/BARS drives membrane fission in dynamin-independent transport pathways | Supplementary information
Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase - pp581 - 590
Ellen J. Ezratty, Michael A. Partridge & Gregg G. Gundersen
doi:10.1038/ncb1262
Abstract - | Full Text - Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase | PDF (2,425 KB) - Microtubule-induced focal adhesion disassembly is mediated by dynamin and focal adhesion kinase | Supplementary information
See also: News and Views by Burridge
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance - pp591 - 600
Jeffrey P. MacKeigan, Leon O. Murphy & John Blenis
doi:10.1038/ncb1258
Abstract - | Full Text - Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance | PDF (601 KB) - Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance | Supplementary information
Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin - pp601 - 611
Yu-Hua Tseng, Atul J. Butte, Efi Kokkotou, Vijay K. Yechoor, Cullen M. Taniguchi, Kristina M. Kriauciunas, Aaron M. Cypess, Michio Niinobe, Kazuaki Yoshikawa, Mary Elizabeth Patti & C. Ronald Kahn
doi:10.1038/ncb1259
Abstract - | Full Text - Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin | PDF (858 KB) - Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin | Supplementary information
Letters
The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization - pp612 - 618
Ophelia Papoulas, Thomas S. Hays & John C. Sisson
doi:10.1038/ncb1264
First Paragraph - | Full Text - The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization | PDF (923 KB) - The golgin Lava lamp mediates dynein-based Golgi movements during Drosophila cellularization | Supplementary information
The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia - pp619 - 625
Antje Schirenbeck, Till Bretschneider, Rajesh Arasada, Michael Schleicher & Jan Faix
doi:10.1038/ncb1266
First Paragraph - | Full Text - The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia | PDF (952 KB) - The Diaphanous-related formin dDia2 is required for the formation and maintenance of filopodia | Supplementary information
Crm1 is a mitotic effector of Ran-GTP in somatic cells - pp626 - 632
Alexei Arnaoutov, Yoshiaki Azuma, Katharina Ribbeck, Jomon Joseph, Yekaterina Boyarchuk, Tatiana Karpova, James McNally & Mary Dasso
doi:10.1038/ncb1263
First Paragraph - | Full Text - Crm1 is a mitotic effector of Ran-GTP in somatic cells | PDF (1,174 KB) - Crm1 is a mitotic effector of Ran-GTP in somatic cells | Supplementary information
See also: News and Views by Clarke
Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies - pp633 - 636
George L. Sen & Helen M. Blau
doi:10.1038/ncb1265
First Paragraph - | Full Text - Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies | PDF (641 KB) - Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies | Supplementary information
