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Letter

Nature Cell Biology 7, 626–632 (1 June 2005) | doi:10.1038/ncb1263

Crm1 is a mitotic effector of Ran-GTP in somatic cells

Alexei Arnaoutov , Yoshiaki Azuma , Katharina Ribbeck , Jomon Joseph , Yekaterina Boyarchuk , Tatiana Karpova , James McNally & Mary Dasso

The Ran GTPase controls multiple cellular processes, including nuclear transport, mitotic checkpoints, spindle assembly and post-mitotic nuclear envelope reassembly. Here we examine the mitotic function of Crm1, the Ran-GTP-binding nuclear export receptor for leucine-rich cargo (bearing nuclear export sequence) and Snurportin-1 (ref.