News and Views

Nature Cell Biology 7, 553 - 555 (2005)
doi:10.1038/ncb0605-553

Transcription RINGs in repair

Mary Ann Osley1

  1. Mary Ann Osley is at the Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Cancer Research Facility 123, 915 Camino de Salud, Albuquerque, NM 87131, USA. e-mail: mosley@salud.unm.edu

A recent study has shown that the Ssl1 subunit of the general transcription/DNA repair factor TFIIH contains ubiquitin ligase activity that is dependent on a RING domain. The RING domain is required for transcription of a subset of yeast genes that are involved in DNA damage repair, thus uncovering a novel ubiquitination-associated function for TFIIH in the repair process.

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