Alexander M. van der Bliek is in the Department of Biological Chemistry, David Geffen School of Medicine at UCLA, 33-257 CHS, Box 951737, Los Angeles, CA 90095-1737, USA. avan@mednet.ucla.edu
It has long been known that the mammalian small GTPase Rab5 is involved in clathrin-mediated endocytosis. However, most Rab5-interacting proteins are localized to endosomes rather than to the plasma membrane. A newly discovered nucleotide-exchange factor for Rab5 in Caenorhabditis elegans now provides the missing link for activating Rab5 at the plasma membrane.
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