Neil A. Hopper and Vincent O'Connor are at the School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. voconno@soton.ac.uk or nah2@soton.ac.uk
Phosphorylation of synaptojanin 1 by the EphB2 receptor tyrosine kinase is a molecular switch. This phosphorylation prevents the interaction of synaptojanin 1 with endophilin and promotes endocytosis. Subsequent dephosphorylation initiates an interaction with endophilin, leading to clathrin uncoating and fusion with endosomes.
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