René Daniel and Roger J. Pomerantz are at The Dorrance H. Hamilton Laboratories, Center for Human Virology and Biodefense, Division of Infectious Diseases and Environmental Medicine, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA. Rene.Daniel@jefferson.edu and Roger.J.Pomerantz@jefferson.edu
The HIV type 1 (HIV-1) life-cycle involves a number of cellular cofactors. Some are essential for HIV-1 replication and thus may serve as targets for therapeutic intervention. An emerging role for cellular DNA repair in HIV-1 infection suggests that inhibition of these repair functions may lead to suppression of viral replication.
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