When domestiques rebel: kinesins, cadherins and neuronal proliferation
Cara J. Gottardi1, Nicole R. den Elzen2
& Alpha S. Yap2
1
Cara J. Gottardi is at the Departments of Medicine and Cell & Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago IL 60611, USA.
2
Nicole R. den Elzen and Alpha S. Yap are at the Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland, Australia 4072. a.yap@imb.uq.edu.au
Conditional knockout of the KAP3 subunit from the kinesin motor KIF3 alters tissue patterning and causes abnormal proliferation of neural progenitor cells in the mouse brain. Impaired transport of N-cadherin to the surface of these cells may be one explanation for how such defects arise.
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