Missed opportunity to ban reproductive cloning - p323

doi:10.1038/ncb0405-323

Full Text - Missed opportunity to ban reproductive cloning | PDF (89 KB) - Missed opportunity to ban reproductive cloning

Promoter usage of BRCA1-IRIS - pp325 - 326

Anders Kvist, Carlos Rovira, Åke Borg & Patrik Medstrand

doi:10.1038/ncb0405-325

Full Text - Promoter usage of BRCA1-IRIS | PDF (148 KB) - Promoter usage of BRCA1-IRIS

Reply to "Promoter usage of BRCA1-IRIS" - p326

Wael M. ElShamy & David M. Livingston

doi:10.1038/ncb0405-326a

Full Text - Reply to "Promoter usage of BRCA1-IRIS" | PDF (81 KB) - Reply to "Promoter usage of BRCA1-IRIS"

Dual role for Bcl-2 in antibody affinity maturation - pp326 - 327

Deborah Dunn-Walters & Jo Spencer

doi:10.1038/ncb0405-326b

Full Text - Dual role for Bcl-2 in antibody affinity maturation | PDF (124 KB) - Dual role for Bcl-2 in antibody affinity maturation

The importance of being Smc5/6 - pp329 - 331

Yoshinori Watanabe

doi:10.1038/ncb0405-329

All members of the conserved family of structural maintenance of chromosomes (SMC) proteins are essential for cellular viability. The Smc1–Smc3 heterodimer is a constituent of cohesin and Smc2–Smc4 of condensin, which are both required for proper chromosome distribution at mitosis. Now, the third SMC heterodimer, Smc5–Smc6, which had previously been implicated only in DNA repair, also turns out to be crucial for chromosome segregation.

Full Text - The importance of being Smc5/6 | PDF (303 KB) - The importance of being Smc5/6

See also: Letter by Torres-Rosell et al.

DUBing down a tumour suppressor - pp332 - 333

Ashok R. Venkitaraman

doi:10.1038/ncb0405-332

Monoubiquitination of the Fanconi anaemia protein FANCD2 is essential for its activity in DNA repair and tumour suppression. The recent identification of a specific de-ubiquitinating (DUB) enzyme for FANCD2 raises intriguing questions about how and why this tumour suppressor becomes deactivated.

Full Text - DUBing down a tumour suppressor | PDF (120 KB) - DUBing down a tumour suppressor

Rho Rocks PTEN - pp334 - 335

Ruedi Meili, Atsuo T. Sasaki & Richard A. Firtel

doi:10.1038/ncb0405-334

Many biological processes require the movement of cells in response to guidance cues. Small GTPases and phosphoinositides are key mediators of the underlying cytoskeletal rearrangements, and a new study establishes that the localization and activation of the phosphoinositide phosphatase PTEN at the rear of chemotaxing neutrophils is mediated by the small GTPase RhoA.

Full Text - Rho Rocks PTEN | PDF (143 KB) - Rho Rocks PTEN

See also: Letter by Li et al.

Cell polarization mechanisms during directed cell migration - pp336 - 337

Anna Huttenlocher

doi:10.1038/ncb0405-336

How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.

Full Text - Cell polarization mechanisms during directed cell migration | PDF (142 KB) - Cell polarization mechanisms during directed cell migration

See also: Article by Nishiya et al.

Directing NGF's actions: it's a Rap - pp338 - 339

Philip J. S. Stork

doi:10.1038/ncb0405-338

Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.

Full Text - Directing NGF's actions: it's a Rap | PDF (210 KB) - Directing NGF's actions: it's a Rap

See also: Article by Sasagawa et al.

A strong root for stem cells - p341

Steve Goldman reviews Handbook on Stem Cells, Volumes 1 and 2 by Robert Lanza

doi:10.1038/ncb0405-341

Full Text - A strong root for stem cells | PDF (75 KB) - A strong root for stem cells

An ₄ integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells - pp343 - 352

Naoyuki Nishiya, William B. Kiosses, Jaewon Han & Mark H. Ginsberg

doi:10.1038/ncb1234

Abstract - | Full Text - An 4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells | PDF (942 KB) - An 4 integrin–paxillin–Arf-GAP complex restricts Rac activation to the leading edge of migrating cells | Supplementary information

See also: News and Views by Huttenlocher

Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics - pp353 - 364

Thierry Dubois, Olivia Paléotti, Alexander A. Mironov, Jr, Vincent Fraisier, Theresia E. B. Stradal, Maria Antonietta De Matteis, Michel Franco & Philippe Chavrier

doi:10.1038/ncb1244

Abstract - | Full Text - Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics | PDF (2,236 KB) - Golgi-localized GAP for Cdc42 functions downstream of ARF1 to control Arp2/3 complex and F-actin dynamics | Supplementary information

Prediction and validation of the distinct dynamics of transient and sustained ERK activation - pp365 - 373

Satoru Sasagawa, Yu-ichi Ozaki, Kazuhiro Fujita & Shinya Kuroda

doi:10.1038/ncb1233

Abstract - | Full Text - Prediction and validation of the distinct dynamics of transient and sustained ERK activation | PDF (1,754 KB) - Prediction and validation of the distinct dynamics of transient and sustained ERK activation | Supplementary information

See also: News and Views by Stork

Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis - pp374 - 380

Mathieu Ingouff, Jonathan N. Fitz Gerald, Christophe Guérin, Hélène Robert, Mikael Blom Sørensen, Daniel Van Damme, Danny Geelen, Laurent Blanchoin & Frédéric Berger

doi:10.1038/ncb1238

First Paragraph - | Full Text - Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis | PDF (957 KB) - Plant formin AtFH5 is an evolutionarily conserved actin nucleator involved in cytokinesis | Supplementary information

Wnt signalling induces maturation of Paneth cells in intestinal crypts - pp381 - 386

Johan H. van Es, Philippe Jay, Alex Gregorieff, Marielle E. van Gijn, Suzanne Jonkheer, Pantelis Hatzis, Andrea Thiele, Maaike van den Born, Harry Begthel, Thomas Brabletz, Makoto M. Taketo & Hans Clevers

doi:10.1038/ncb1240

First Paragraph - | Full Text - Wnt signalling induces maturation of Paneth cells in intestinal crypts | PDF (1,260 KB) - Wnt signalling induces maturation of Paneth cells in intestinal crypts | Supplementary information

CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability - pp387 - 391

Susan Wee, Rory K. Geyer, Takashi Toda & Dieter A. Wolf

doi:10.1038/ncb1241

First Paragraph - | Full Text - CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability | PDF (460 KB) - CSN facilitates Cullin–RING ubiquitin ligase function by counteracting autocatalytic adapter instability | Supplementary information

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition - pp392 - 398

Kathrine Abell, Antonio Bilancio, Richard W. E. Clarkson, Paul G. Tiffen, Anton I. Altaparmakov, Thomas G. Burdon, Tomoichiro Asano, Bart Vanhaesebroeck & Christine J. Watson

doi:10.1038/ncb1242

First Paragraph - | Full Text - Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition | PDF (430 KB) - Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

Regulation of PTEN by Rho small GTPases - pp399 - 404

Zhong Li, Xuemei Dong, Zhenglong Wang, Wenzhong Liu, Ning Deng, Yu Ding, Liuya Tang, Tim Hla, Rong Zeng, Lin Li & Dianqing Wu

doi:10.1038/ncb1236

First Paragraph - | Full Text - Regulation of PTEN by Rho small GTPases | PDF (1,407 KB) - Regulation of PTEN by Rho small GTPases | Supplementary information

See also: News and Views by Meili et al.

Spinophilin regulates Ca²⁺ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors - pp405 - 411

Xinhua Wang, Weizhong Zeng, Abigail A. Soyombo, Wei Tang, Elliott M. Ross, Anthony P. Barnes, Sharon L. Milgram, Josef M. Penninger, Patrick B. Allen, Paul Greengard & Shmuel Muallem

doi:10.1038/ncb1237

First Paragraph - | Full Text - Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors | PDF (549 KB) - Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions - pp412 - 419

Jordi Torres-Rosell, Félix Machín, Sarah Farmer, Adam Jarmuz, Trevor Eydmann, Jacob Z. Dalgaard & Luis Aragón

doi:10.1038/ncb1239

First Paragraph - | Full Text - SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions | PDF (1,019 KB) - SMC5 and SMC6 genes are required for the segregation of repetitive chromosome regions | Supplementary information

See also: News and Views by Watanabe

Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin - pp420 - 428

Susana Gonzalo, Marta García-Cao, Mario F. Fraga, Gunnar Schotta, Antoine H.F.M. Peters, Shane E. Cotter, Raúl Eguía, Douglas C. Dean, Manel Esteller, Thomas Jenuwein & María A. Blasco

doi:10.1038/ncb1235

First Paragraph - | Full Text - Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin | PDF (1,813 KB) - Role of the RB1 family in stabilizing histone methylation at constitutive heterochromatin | Supplementary information

Active intranuclear movement of herpesvirus capsids - pp429 - 431

Thomas Forest, Sandra Barnard & Joel D. Baines

doi:10.1038/ncb1243

Abstract - | Full Text - Active intranuclear movement of herpesvirus capsids | PDF (283 KB) - Active intranuclear movement of herpesvirus capsids | Supplementary information

Corrigendum - p431

doi:10.1038/ncb1245

Full Text - Corrigendum | PDF (33 KB) - Corrigendum