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Letter

Nature Cell Biology 7, 392–398 (1 April 2005) | doi:10.1038/ncb1242

Stat3-induced apoptosis requires a molecular switch in PI(3)K subunit composition

Kathrine Abell , Antonio Bilancio , Richard W. E. Clarkson , Paul G. Tiffen , Anton I. Altaparmakov , Thomas G. Burdon , Tomoichiro Asano , Bart Vanhaesebroeck & Christine J. Watson

Physiological apoptosis is induced by a switch from survival to death signalling. Dysregulation of this process is frequently associated with cancer.