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Letter

Nature Cell Biology 7, 405–411 (1 April 2005) | doi:10.1038/ncb1237

Spinophilin regulates Ca2+ signalling by binding the N-terminal domain of RGS2 and the third intracellular loop of G-protein-coupled receptors

Xinhua Wang , Weizhong Zeng , Abigail A. Soyombo , Wei Tang , Elliott M. Ross , Anthony P. Barnes , Sharon L. Milgram , Josef M. Penninger , Patrick B. Allen , Paul Greengard & Shmuel Muallem

Signalling by G proteins is controlled by the regulator of G-protein signalling (RGS) proteins that accelerate the GTPase activity of Gα subunits and act in a G-protein-coupled receptor (GPCR)-specific manner. The conserved RGS domain accelerates the G subunit GTPase activity, whereas the variable amino-terminal domain participates in GPCR recognition.