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Nature Cell Biology 7, 334–335 (1 April 2005) | doi:10.1038/ncb0405-334
Rho Rocks PTEN
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Abstract
Chemotaxis of cells requires three key processes: cell alignment along the chemoattractant gradient; cell polarization; and protrusion and retraction of cytoskeletal elements leading to net movement towards the attractant source. Many of the mechanisms controlling these processes have been defined using two experimental systems — mammalian neutrophils and the amoebae Dictyostelium — and the underlying mechanisms in both systems are similar.
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