Philip J. S. Stork is at the Oregon Health Sciences University, Vollum Institute L-474, 3181 SW Sam Jackson Park Road, Portland, OR 97201-3098, USA. stork@ohsu.edu
Epidermal growth factor and nerve growth factor (NGF) lead to significantly different temporal patterns of extracellular-signal-regulated kinase activation, and differential regulation of Ras and Rap1 have been implicated in mediating this temporal specificity. Now Sasagawa et al. derive a computational model that incorporates the known signalling interactions and identifies key points of regulation that control these processes.
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