1. Anna Huttenlocher is at the Departments of Pharmacology and Pediatrics, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA. e-mail: huttenlocher@wisc.edu

Abstract

How cells establish and maintain polarity during directed cell migration remains poorly understood. Nishiya et al. now describe an integrin signalling complex that includes paxillin and GIT1, which limits activation of Rac to the leading edge of a migrating cell.

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