1. Ashok R. Venkitaraman is at the University of Cambridge, Cancer Research UK Department of Oncology & The Medical Research Council Cancer Cell Unit, Hills Road, Cambridge CB2 2XZ, UK. e-mail: arv22@cam.ac.uk

Abstract

Monoubiquitination of the Fanconi anaemia protein FANCD2 is essential for its activity in DNA repair and tumour suppression. The recent identification of a specific de-ubiquitinating (DUB) enzyme for FANCD2 raises intriguing questions about how and why this tumour suppressor becomes deactivated.

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