Yoshinori Watanabe is at the Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, and SORST, Japan Science and Technology Agency, Yayoi, Tokyo 113-0032, Japan. ywatanab@iam.u-tokyo.ac.jp
All members of the conserved family of structural maintenance of chromosomes (SMC) proteins are essential for cellular viability. The Smc1−Smc3 heterodimer is a constituent of cohesin and Smc2−Smc4 of condensin, which are both required for proper chromosome distribution at mitosis. Now, the third SMC heterodimer, Smc5−Smc6, which had previously been implicated only in DNA repair, also turns out to be crucial for chromosome segregation.
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