1. Yoshinori Watanabe is at the Laboratory of Chromosome Dynamics, Institute of Molecular and Cellular Biosciences, University of Tokyo, and SORST, Japan Science and Technology Agency, Yayoi, Tokyo 113-0032, Japan. e-mail: ywatanab@iam.u-tokyo.ac.jp

Abstract

All members of the conserved family of structural maintenance of chromosomes (SMC) proteins are essential for cellular viability. The Smc1–Smc3 heterodimer is a constituent of cohesin and Smc2–Smc4 of condensin, which are both required for proper chromosome distribution at mitosis. Now, the third SMC heterodimer, Smc5–Smc6, which had previously been implicated only in DNA repair, also turns out to be crucial for chromosome segregation.

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