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Editorial

Policy update p203

doi:10.1038/ncb0305-203


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News and Views

Pars and polarity: taking control of Rac pp205 - 207

Toby W. Hurd & Ben Margolis

doi:10.1038/ncb0305-205

In this issue, two groups have examined the role of the Par proteins in the regulation of small G proteins, in two different models of cell polarity — mammalian epithelia and neuronal axon specification. They concurrently report the intriguing finding that the Par-3/Par-6/aPKC complex can regulate the activation of Rac by interaction with the guanine nucleotide exchanger, Tiam1/STEF. Furthermore, they also demonstrate a hitherto under-appreciated role for the Par-3/Par-6/aPKC complex in the regulation of the actin cytoskeleton.

See also: Letter by Chen & Macara | Letter by Nishimura et al.


Cdc48–Ufd2–Rad23: the road less ubiquitinated? pp207 - 209

Omar A. Bazirgan & Randolph Y. Hampton

doi:10.1038/ncb0305-207

Targeting substrates to the proteasome is generally thought to depend on long polyubiquitin chains that form on the substrate. Recent work has led to the provocative proposal that some substrates may be targeted to the proteasome through smaller chains that contain only four to six ubiquitin molecules.


An endocytic Prk-ing brake pp210 - 212

Mara C. Duncan & Gregory S. Payne

doi:10.1038/ncb0305-210

Actin polymerization is intimately associated with endocytosis in yeast and mammalian cells. Mechanisms of actin filament assembly in endocytosis are becoming better understood but less is known about how assembly is terminated. In yeast, phosphorylation of Arp2/3 complex activators provides one mechanism for downregulating endocytic actin assembly.

See also: Letter by Toshima et al.


Growth factor control of autophagy p212

Markus Wagner

doi:10.1038/ncb0305-212


Stress and death: breaking up the c-Abl/14-3-3 complex in apoptosis pp213 - 214

Ann Marie Pendergast

doi:10.1038/ncb0305-213

Nuclear accumulation of the c-Abl tyrosine kinase is associated with a pro-apoptotic response after DNA damage, but the mechanism regulating c-Abl nuclear localization is unclear. DNA damage and other stress signals are now shown to induce phosphorylation of 14-3-3 proteins by the c-Jun amino-terminal kinase, disrupting a c-Abl/14-3-3 cytoplasmic complex, and liberating c-Abl for translocation to the nucleus.

See also: Letter by Yoshida et al.


The Myc trilogy: lord of RNA polymerases pp215 - 217

Thordur Oskarsson & Andreas Trumpp

doi:10.1038/ncb0305-215

Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.

See also: Letter by Grewal et al. | Letter by Grandori et al. | Letter by Arabi et al.


Nucleolar targeting runs on GTP cycles p217

Sowmya Swaminathan

doi:10.1038/ncb0305-217


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Perspective

Spindle assembly: asters part their separate ways pp219 - 222

Jody Rosenblatt

doi:10.1038/ncb0305-219


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Book Review

A new tome for the centrosome p223

Kevin O'Connell reviews Centrosomes in Development and Disease by Erich Nigg

doi:10.1038/ncb0305-223


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Articles

Maintenance of the diacylglycerol level in the Golgi apparatus by the Nir2 protein is critical for Golgi secretory function pp225 - 234

Vladimir Litvak, Nili Dahan, Sreekumar Ramachandran, Helena Sabanay & Sima Lev

doi:10.1038/ncb1221


Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphase pp235 - 245

Vito Mennella, Gregory C. Rogers, Stephen L. Rogers, Daniel W. Buster, Ronald D. Vale & David J. Sharp

doi:10.1038/ncb1222


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Letters

Phosphoregulation of Arp2/3-dependent actin assembly during receptor-mediated endocytosis pp246 - 254

Jiro Toshima, Junko Y. Toshima, Adam C. Martin & David G. Drubin

doi:10.1038/ncb1229

See also: News and Views by Duncan & Payne


Cdc42–MRCK and Rho–ROCK signalling cooperate in myosin phosphorylation and cell invasion pp255 - 261

Simon Wilkinson, Hugh F. Paterson & Christopher J. Marshall

doi:10.1038/ncb1230



PAR-6–PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1 pp270 - 277

Takashi Nishimura, Tomoya Yamaguchi, Katsuhiro Kato, Masato Yoshizawa, Yo-ichi Nabeshima, Shigeo Ohno, Mikio Hoshino & Kozo Kaibuchi

doi:10.1038/ncb1227

See also: News and Views by Hurd & Margolis


JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage pp278 - 285

Kiyotsugu Yoshida, Tomoko Yamaguchi, Tohru Natsume, Donald Kufe & Yoshio Miki

doi:10.1038/ncb1228

See also: News and Views by Pendergast


Atrophy of S6K1-/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control pp286 - 294

Mickaël Ohanna, Andrew K. Sobering, Thomas Lapointe, Lazaro Lorenzo, Christophe Praud, Emmanuel Petroulakis, Nahum Sonenberg, Paul A. Kelly, Athanassia Sotiropoulos & Mario Pende

doi:10.1038/ncb1231


Myc-dependent regulation of ribosomal RNA synthesis during Drosophila development pp295 - 302

Savraj S. Grewal, Ling Li, Amir Orian, Robert N. Eisenman & Bruce A. Edgar

doi:10.1038/ncb1223

See also: News and Views by Oskarsson & Trumpp


c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription pp303 - 310

Azadeh Arabi, Siqin Wu, Karin Ridderstråle, Holger Bierhoff, Chiounan Shiue, Karoly Fatyol, Sara Fahlén, Per Hydbring, Ola Söderberg, Ingrid Grummt, Lars-Gunnar Larsson & Anthony P. H. Wright

doi:10.1038/ncb1225

See also: News and Views by Oskarsson & Trumpp


c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I pp311 - 318

Carla Grandori, Natividad Gomez-Roman, Zoe A. Felton-Edkins, Celine Ngouenet, Denise A. Galloway, Robert N. Eisenman & Robert J. White

doi:10.1038/ncb1224

See also: News and Views by Oskarsson & Trumpp


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Brief Communication

Imaging of single light-responsive clock cells reveals fluctuating free-running periods pp319 - 321

Amanda-Jayne F. Carr & David Whitmore

doi:10.1038/ncb1232


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