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Letter

Nature Cell Biology 7, 303–310 (1 March 2005) | doi:10.1038/ncb1225

c-Myc associates with ribosomal DNA and activates RNA polymerase I transcription

Azadeh Arabi , Siqin Wu , Karin Ridderstr|[aring]|le , Holger Bierhoff , Chiounan Shiue , Karoly Fatyol , Sara Fahl|[eacute]|n , Per Hydbring , Ola S|[ouml]|derberg , Ingrid Grummt , Lars-Gunnar Larsson & Anthony P. H. Wright

The c-Myc oncoprotein regulates transcription of genes that are associated with cell growth, proliferation and apoptosis. c-Myc levels are modulated by ubiquitin/proteasome-mediated degradation.