Jody Rosenblatt is at the MRC-Laboratory for Molecular Cell Biology, University College London, London WC1E 6BT, UK jody.rosenblatt@ucl.ac.uk
Cells have developed diverse ways to separate two microtubule asters to form a mitotic spindle. Here, I focus on two mechanisms used to position asters around chromosomes during mitosis: first, aster migration around the nuclear envelope and, second, aster attachment to a contractile cortex at the plasma membrane after the nuclear envelope has broken down. Although certain cell types use one mechanism predominantly, most rely on both to ensure proper spindle assembly.
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