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Nature Cell Biology 7, 215 - 217 (2005)
doi:10.1038/ncb0305-215
The Myc trilogy: lord of RNA polymerases
Thordur Oskarsson1 & Andreas Trumpp1
- Thordur Oskarsson and Andreas Trumpp are at the Swiss Institute for Experimental Cancer Research (ISREC), 1066 Epalinges, Switzerland. e-mail: andreas.trumpp@isrec.ch
Abstract
Cancer cells have a raised cellular metabolism, including increased protein biosynthesis. Three new studies now show that the oncoprotein Myc, known to drive cell division, also enhances ribosomal RNA synthesis by RNA polymerase I in addition to controlling RNA polymerase II- and III-regulated gene transcription. This suggests that Myc promotes the generation of crucial components of a functional ribosome.
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