1. Toby W. Hurd and Ben Margolis are at the Howard Hughes Medical Institute, University of Michigan Medical School, Ann Arbor, MI 48109-2216, USA.
2. Ben Margolis is also affiliated with the Department of Internal Medicine and the Department of Biological Chemistry, University of Michigan Medical School, Ann Arbor, MI 48109-2216, USA. e-mail: bmargoli@mail.umich.edu

Abstract

In this issue, two groups have examined the role of the Par proteins in the regulation of small G proteins, in two different models of cell polarity — mammalian epithelia and neuronal axon specification. They concurrently report the intriguing finding that the Par-3/Par-6/aPKC complex can regulate the activation of Rac by interaction with the guanine nucleotide exchanger, Tiam1/STEF. Furthermore, they also demonstrate a hitherto under-appreciated role for the Par-3/Par-6/aPKC complex in the regulation of the actin cytoskeleton.

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