A mismatched role for Bcl-2 - pp101 - 102

Nicholas B. La Thangue

doi:10.1038/ncb0205-101

Bcl-2 has previously been characterized as an anti-apoptotic protein. However, it has now been linked to DNA mismatch repair (MMR). By retaining E2F-1 in a transcriptionally inactive state, through the induction of hypophosphorylated retinoblastoma protein, Bcl-2 hinders the expression of a key component of mismatch repair, MSH2. This study could therefore help to explain the mutagenicity that is associated with Bcl-2.

Full Text - A mismatched role for Bcl-2 | PDF (126 KB) - A mismatched role for Bcl-2

See also: Article by Youn et al.

Expanding dynamin: from fission to fusion - pp103 - 104

Karolina Peplowska & Christian Ungermann

doi:10.1038/ncb0205-103

How cells maintain the balance between membrane fission and fusion is not known. Recent results show that Vps1p, a yeast dynamin-like protein, is involved in both processes at the vacuole, indicating that these two antagonistic reactions might be connected after all.

Full Text - Expanding dynamin: from fission to fusion | PDF (156 KB) - Expanding dynamin: from fission to fusion

TRPs as mechanosensitive channels - pp105 - 107

Greg Barritt & Grigori Rychkov

doi:10.1038/ncb0205-105

Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.

Full Text - TRPs as mechanosensitive channels | PDF (203 KB) - TRPs as mechanosensitive channels

See also: Letter by Maroto et al.

Spire: a new nucleator for actin - p107

Alison Schuldt

doi:10.1038/ncb0205-107

Full Text - Spire: a new nucleator for actin | PDF (127 KB) - Spire: a new nucleator for actin

FoxM1 dances with mitosis - pp108 - 110

Robert H. Costa

doi:10.1038/ncb0205-108

The mammalian Forkhead Box M1 (FoxM1) protein, known for its function as a transcriptional regulator of G1/S progression, is also crucial for the G2/M transition. Some of its target genes are cyclin B, Cdc25B phosphatase, Aurora B kinase and Polo-like kinase. Furthermore, identification of the nuclear protein CENP-F as a transcriptional target of FoxM1 reveals how it can also regulate the spindle assembly checkpoint, thereby ensuring proper chromosome stability and segregation during mitosis.

Full Text - FoxM1 dances with mitosis | PDF (151 KB) - FoxM1 dances with mitosis

See also: Article by Laoukili et al.

Maclyn McCarty, 1911–2005 - p111

Emil Gotschlich & Kathleen Gotschlich

doi:10.1038/ncb0205-111

Full Text - Maclyn McCarty, 1911–2005 | PDF (158 KB) - Maclyn McCarty, 1911–2005

The networking cytoskeleton - p113

Sue Wick reviews The Plant Cytoskeleton in Cell Differentiation and Development by Patrick Hussey

doi:10.1038/ncb0205-113

Full Text - The networking cytoskeleton | PDF (94 KB) - The networking cytoskeleton

Creating controversy - p99

doi:10.1038/ncb0205-99

Full Text - Creating controversy | PDF (79 KB) - Creating controversy

p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression - pp165 - 171

Tongxiang Lin, Connie Chao, Shin'ichi Saito, Sharlyn J. Mazur, Maureen E. Murphy, Ettore Appella & Yang Xu

doi:10.1038/ncb1211

First Paragraph - p53 induces differentiation of mouse embryonic stem cells by suppressing : Nanog: expression | Full Text - p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression | PDF (518 KB) - p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression | Supplementary information

The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair - pp195 - 201

Claus Storgaard Sørensen, Lasse Tengbjerg Hansen, Jaroslaw Dziegielewski, Randi G. Syljuåsen, Cecilia Lundin, Jiri Bartek & Thomas Helleday

doi:10.1038/ncb1212

First Paragraph - The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair | Full Text - The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair | PDF (841 KB) - The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair | Supplementary information

OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes - pp186 - 194

Shinichi Kondo, Tomohiko Murakami, Kouko Tatsumi, Maiko Ogata, Soshi Kanemoto, Kumi Otori, Ken Iseki, Akio Wanaka & Kazunori Imaizumi

doi:10.1038/ncb1213

First Paragraph - OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | Full Text - OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | PDF (1,948 KB) - OASIS, a CREB/ATF-family member, modulates UPR signalling in astrocytes | Supplementary information

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells - pp172 - 178

Carl R. Walkley, Matthew L. Fero, Wei-Ming Chien, Louise E. Purton & Grant A. McArthur

doi:10.1038/ncb1214

First Paragraph - Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells | Full Text - Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells | PDF (525 KB) - Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells | Supplementary information

Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity - pp137 - 147

Cha-Kyung Youn, Hyun-Ju Cho, Soo-Hyun Kim, Hong-Beum Kim, Mi-Hwa Kim, In-Youb Chang, Jung-Sup Lee, Myung-Hee Chung, Kyung-Soo Hahm & Ho Jin You

doi:10.1038/ncb1215

Abstract - Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity | Full Text - Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity | PDF (683 KB) - Bcl-2 expression suppresses mismatch repair activity through inhibition of E2F transcriptional activity | Supplementary information

See also: News and Views by La Thangue

Basic mechanism of three-dimensional collagen fibre transport by fibroblasts - pp157 - 164

Adam S. Meshel, Qize Wei, Robert S. Adelstein & Michael P. Sheetz

doi:10.1038/ncb1216

First Paragraph - Basic mechanism of three-dimensional collagen fibre transport by fibroblasts | Full Text - Basic mechanism of three-dimensional collagen fibre transport by fibroblasts | PDF (1,443 KB) - Basic mechanism of three-dimensional collagen fibre transport by fibroblasts | Supplementary information

FoxM1 is required for execution of the mitotic programme and chromosome stability - pp126 - 136

Jamila Laoukili, Matthijs R. H. Kooistra, Alexandra Brás, Jos Kauw, Ron M. Kerkhoven, Ashby Morrison, Hans Clevers & René H. Medema

doi:10.1038/ncb1217

Abstract - FoxM1 is required for execution of the mitotic programme and chromosome stability | Full Text - FoxM1 is required for execution of the mitotic programme and chromosome stability | PDF (938 KB) - FoxM1 is required for execution of the mitotic programme and chromosome stability | Supplementary information

See also: News and Views by Costa

TRPC1 forms the stretch-activated cation channel in vertebrate cells - pp179 - 185

Rosario Maroto, Albert Raso, Thomas G. Wood, Alex Kurosky, Boris Martinac & Owen P. Hamill

doi:10.1038/ncb1218

First Paragraph - TRPC1 forms the stretch-activated cation channel in vertebrate cells | Full Text - TRPC1 forms the stretch-activated cation channel in vertebrate cells | PDF (1,192 KB) - TRPC1 forms the stretch-activated cation channel in vertebrate cells | Supplementary information

See also: News and Views by Barritt & Rychkov

Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia - pp148 - 156

Inna A. Belyantseva, Erich T. Boger, Sadaf Naz, Gregory I. Frolenkov, James R. Sellers, Zubair M. Ahmed, Andrew J. Griffith & Thomas B. Friedman

doi:10.1038/ncb1219

First Paragraph - Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia | Full Text - Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia | PDF (1,694 KB) - Myosin-XVa is required for tip localization of whirlin and differential elongation of hair-cell stereocilia | Supplementary information

SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells - pp115 - 125

Sebastian Leidel, Marie Delattre, Lorenzo Cerutti, Karine Baumer & Pierre Gönczy

doi:10.1038/ncb1220

Abstract - SAS-6 defines a protein family required for centrosome duplication in : C. elegans: and in human cells | Full Text - SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells | PDF (1,773 KB) - SAS-6 defines a protein family required for centrosome duplication in C. elegans and in human cells | Supplementary information