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Letter
Nature Cell Biology 7, 179–185 (1 February 2005) | doi:10.1038/ncb1218
TRPC1 forms the stretch-activated cation channel in vertebrate cells
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Abstract
The mechanosensitive cation channel (MscCa) transduces membrane stretch into cation (Na+, K+, Ca2+ and Mg2+) flux across the cell membrane, and is implicated in cell-volume regulation, cell locomotion, muscle dystrophy and cardiac arrhythmias. However, the membrane protein(s) that form the MscCa in vertebrates remain unknown.
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