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Letter
Nature Cell Biology 7, 165–171 (1 February 2005) | doi:10.1038/ncb1211
p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
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Abstract
The tumour suppressor p53 becomes activated in response to upstream stress signals, such as DNA damage, and causes cell-cycle arrest or apoptosis. Here we report a novel role for p53 in the differentiation of mouse embryonic stem cells (ESCs).
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