1. Greg Barritt is at the Department of Medical Biochemistry, School of Medicine, Faculty of Health Sciences, Flinders University, GPO Box 2100, Adelaide, SA 5001, Australia. e-mail: greg.barritt@flinders.edu.au
2. Grigori Rychkov is at the Department of Physiology, School of Molecular and Biomedical Science, University of Adelaide, Adelaide, SA 5005, Australia. e-mail: grigori.rychkov@adelaide.edu.au

Abstract

Mechanosensitive channels are essential for effective cellular function, but elucidation of their molecular identity and mechanisms of activation has proven difficult. Two recent studies now implicate members of the transient receptor potential (TRP) family as components of the mechanosensitive channels in vertebrate hair cells (TRPA1) and stretch-activated channels (TRPC1) in several different vertebrate cell types.

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