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Nature Cell Biology 7, 1157–1158 (1 December 2005) | doi:10.1038/ncb1205-1057

Pins for spines

Juergen A. Knoblich

Heterotrimeric G proteins are known for their role in signal transduction downstream of seven-transmembrane-spanning receptors. When receptors are activated, GDP–GTP exchange on the α-subunit of the heterotrimer releases the βγ-subunit.