Figure 2 - Genetic interactions between dx and krz mutations.

(a–l) Representative wings from males with indicated genotypes. Wings from krz¹ (b) and krz² (c) heterozygotes are indistinguishable from wild-type (wt) control wings (a). dx (d, g) and dx^SM (j) show wing phenotypes that consist of notched wing margins and extra vein material, especially at the distal ends of wing veins. Both dx alleles show an enhancement of wing notching and vein thickening in hemizygous combinations with either krz¹ (e, h, k) or krz² (f, i, l) heterozygotes. Images in g–i are high-magnification images of the distal ends of wings shown in d–f, respectively. (m) Mutations in krz suppress the ability of dx to rescue the semilethality that is associated with a transheterozygous combination of two Notch alleles. Survival of females carrying two Abruptex alleles, Ax^9B2 and Ax^E2, was tested in the presence of a control FRT82B chromosome (column 1) or in the presence of the same chromosome carrying krz¹ or krz² mutations (columns 2 and 3). Mutations in krz did not rescue Ax^9B2/Ax^E2 semilethality. However, introduction of one copy of the dx^ENU allele rescued Ax semilethality to 26% (column 4), whereas further addition of one copy of either krz¹ or krz² reduced this rescue to 14% and 12%, respectively (columns 5 and 6). Scale bars, 500 m (a–f and j–l), 200 m (g–i).