Article abstract
Nature Cell Biology 7, 1191 - 1201 (2005)
Published online: 13 November 2005 | doi:10.1038/ncb1327
There is an Erratum (December 2005) associated with this Article.
Regulation of Notch signalling by non-visual 
-arrestin
Ashim Mukherjee1,6, Alexey Veraksa1,2,6, Andreas Bauer3, Carine Rosse4, Jacques Camonis4 & Spyros Artavanis-Tsakonas1,5
Abstract
Signalling activity of the Notch receptor, which plays a fundamental role in metazoan cell fate determination, is controlled at multiple levels. We uncovered a Notch signal-controlling mechanism that depends on the ability of the non-visual 
-arrestin, Kurtz (Krz), to influence the degradation and, consequently, the function of the Notch receptor. We identified Krz as a binding partner of a known Notch-pathway modulator, Deltex (Dx), and demonstrated the existence of a trimeric Notch–Dx–Krz protein complex. This complex mediates the degradation of the Notch receptor through a ubiquitination-dependent pathway. Our results establish a novel mode of regulation of Notch signalling and define a new function for non-visual -arrestins.
- Department of Cell Biology, Harvard Medical School, Massachusetts General Hospital Cancer Center, Charlestown, MA 02129, USA.
- Present address: Biology Department, University of Massachusetts Boston, Boston, MA 02125, USA.
- Cellzome AG, Heidelberg 69117, Germany.
- Institut Curie, Inserm U-528, 75248 Paris Cedex 05, France.
- Collège de France, 11 place Marcelin Berthelot, 75231, Paris, Cedex 05, France.
- These authors contributed equally to this work.
Correspondence to: Spyros Artavanis-Tsakonas1,5 e-mail: tsakonas@helix.mgh.harvard.edu
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