News and Views
Nature Cell Biology 7, 1164 - 1165 (2005)
doi:10.1038/ncb1205-1164
Polycystins: inhibiting the inhibitors
Robert Benezra1
- Robert Benezra is in the Memorial Sloan-Kettering Cancer Center, Box 241, 1275 York Avenue, New York City, NY 10021, USA. e-mail: r-benezra@ski.mskcc.org
Abstract
Polycystin-1 and -2 — two integral membrane proteins that are mutated in polycystic kidney disease — regulate the cell cycle by preventing nuclear localization of the pro-proliferative helix-loop-helix (HLH) protein Id2. This novel mechanism for restraining Id proteins has important implications for our understanding of the nature of polycystic kidney disease and perhaps other proliferative disorders.
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Polycystins: inhibiting the inhibitorsNature Cell Biology News and Views (01 Dec 2005)
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