News and Views
Nature Cell Biology 7, 1161 - 1163 (2005)
doi:10.1038/ncb1205-1061
There is an Erratum (December 2005) associated with this News and Views.
Apoptosis: eating sensibly
Christopher D. Gregory1 & Simon B. Brown1
- Christopher D. Gregory and Simon Brown are in the University of Edinburgh/MRC Centre for Inflammation Research, Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, UK. e-mail: chris.gregory@ed.ac.uk
Abstract
Phagocytes may engulf both apoptotic and viable cells via calreticulin on the surface of the target cell, through its interaction with the phagocyte receptor, LRP. In reality, however, only apoptotic cells are engulfed, apparently because their surface ligand CD47 is prevented from activating the inhibitory phagocyte receptor SIRP
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