Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Volume 7 Issue 11, November 2005

Tankyrase-1, and the poly(ADPribose) it polymerizes, are required for mitotic spindle function. Knock-down of the protein in HeLa cells leads to spindle pole splitting, and loss of spindle bipolarity as shown in this electron micrograph.

Volume 7 Issue 11

Subscribe

Editorial

Top of page ⤴

Book Review

Top of page ⤴

Review Article

Top of page ⤴

News & Views

  • An increase in the size of the amyloid β-peptide (Aβ42 versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

    • Mark P. Mattson
    • Roy G. Cutler
    • Dong-Gyu Jo
    News & Views

  • Receptor-independent G-protein signalling regulates both the orientation and position of the mitotic spindle during asymmetric cell division. Several new studies show that the targeting of G-protein subunits to the membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and -independent pathways.

    • Fumio Matsuzaki
    News & Views

  • How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.

    • Lei Chen
    • Robert S. Kass
    News & Views

  • Guidance molecules ensure that nerve cells grow in the correct direction during brain development. However, very little is known about the signals transmitted by these molecules. It now seems that netrin-1 — the first guidance molecule discovered — achieves this, in part, through activation of PITPα, a protein involved in lipid transfer.

    • Patrick Mehlen
    • Agnès Bernet
    News & Views

  • A new paradigm for gene control has emerged — retaining mRNA in the nucleus to prevent its translation until the gene product is urgently needed.

    • Asis K. Das
    • Gordon G. Carmichael
    News & Views
Top of page ⤴

Article

Top of page ⤴

Letter

Top of page ⤴

Erratum

Top of page ⤴

Search

Advanced search

Quick links