Table of contents
November 2005, Volume 7 No 11 pp1037-1147
About the coverEditorials
Policy matters, policies that matter - p1037
doi:10.1038/ncb1105-1037a
Full Text - Policy matters, policies that matter | PDF (93 KB) - Policy matters, policies that matter
Reviewing peer review - p1037
doi:10.1038/ncb1105-1037b
Full Text - Reviewing peer review | PDF (94 KB) - Reviewing peer review
Book Review
The cosmic surprise - p1038
Robert N. Eisenman reviews Vital Harmonies: Molecular Biology and our Shared Humanity by Erwin Fleissner
doi:10.1038/ncb1105-1038
Full Text - The cosmic surprise | PDF (94 KB) - The cosmic surprise
Review
Prion domains: sequences, structures and interactions - pp1039 - 1044
Eric D. Ross, Allen Minton & Reed B. Wickner
doi:10.1038/ncb1105-1039
Abstract - | Full Text - Prion domains: sequences, structures and interactions | PDF (262 KB) - Prion domains: sequences, structures and interactions
News and Views
Alzheimer peptides perturb lipid-regulating enzymes - pp1045 - 1047
Mark P. Mattson, Roy G. Cutler & Dong-Gyu Jo
doi:10.1038/ncb1105-1045
An increase in the size of the amyloid
-peptide (A
42 versus A
40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the A
42:A
40 ratio may cause dysfunction and death of neurons.
Full Text - Alzheimer peptides perturb lipid-regulating enzymes | PDF (164 KB) - Alzheimer peptides perturb lipid-regulating enzymes
See also: Letter by Grimm et al.
Drosophila G-protein signalling: intricate roles for Ric-8? - pp1047 - 1049
Fumio Matsuzaki
doi:10.1038/ncb1105-1047
Receptor-independent G-protein signalling regulates both the orientation and position of the mitotic spindle during asymmetric cell division. Several new studies show that the targeting of G-protein subunits to the membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and -independent pathways.
Full Text - Drosophila G-protein signalling: intricate roles for Ric-8? | PDF (225 KB) - Drosophila G-protein signalling: intricate roles for Ric-8?
See also: Letter by David et al. | Letter by Wang et al. | Letter by Hampoelz et al.
A-kinase anchoring proteins: different partners, different dance - pp1050 - 1051
Lei Chen & Robert S. Kass
doi:10.1038/ncb1105-1050
How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.
Full Text - A-kinase anchoring proteins: different partners, different dance | PDF (238 KB) - A-kinase anchoring proteins: different partners, different dance
See also: Article by Hoshi et al.
Netrin PIPes up - pp1052 - 1053
Patrick Mehlen & Agnès Bernet
doi:10.1038/ncb1105-1052
Guidance molecules ensure that nerve cells grow in the correct direction during brain development. However, very little is known about the signals transmitted by these molecules. It now seems that netrin-1 — the first guidance molecule discovered — achieves this, in part, through activation of PITP
, a protein involved in lipid transfer.
Full Text - Netrin PIPes up | PDF (139 KB) - Netrin PIPes up
See also: Letter by Xie et al.
Unleash the messenger - pp1054 - 1055
Asis K. Das & Gordon G. Carmichael
doi:10.1038/ncb1105-1054
A new paradigm for gene control has emerged — retaining mRNA in the nucleus to prevent its translation until the gene product is urgently needed.
Full Text - Unleash the messenger | PDF (177 KB) - Unleash the messenger
Autophagy: to die or not to die - p1056
Myrto Raftopoulou
doi:10.1038/ncb1105-1056
Full Text - Autophagy: to die or not to die | PDF (175 KB) - Autophagy: to die or not to die
Articles
Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal - pp1057 - 1065
Ranjan Swarup, Eric M. Kramer, Paula Perry, Kirsten Knox, H. M. Ottoline Leyser, Jim Haseloff, Gerrit T. S. Beemster, Rishikesh Bhalerao & Malcolm J. Bennett
doi:10.1038/ncb1316
Abstract - | Full Text - Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal | PDF (1,279 KB) - Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal | Supplementary information
Distinct enzyme combinations in AKAP signalling complexes permit functional diversity - pp1066 - 1073
Naoto Hoshi, Lorene K. Langeberg & John D. Scott
doi:10.1038/ncb1315
Abstract - | Full Text - Distinct enzyme combinations in AKAP signalling complexes permit functional diversity | PDF (1,418 KB) - Distinct enzyme combinations in AKAP signalling complexes permit functional diversity | Supplementary information
See also: News and Views by Chen & Kass
The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene - pp1074 - 1082
Benjamin D. Rowland, René Bernards & Daniel S. Peeper
doi:10.1038/ncb1314
Abstract - | Full Text - The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene | PDF (688 KB) - The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene | Supplementary information
Letters
Drosophila Ric-8 regulates G
i cortical localization to promote G
i-dependent planar orientation of the mitotic spindle during asymmetric cell division - pp1083 - 1090
Nicolas B. David, Charlotte A. Martin, Marion Segalen, François Rosenfeld, François Schweisguth & Yohanns Bellaïche
doi:10.1038/ncb1319
First Paragraph - | Full Text - Drosophila Ric-8 regulates G
i cortical localization to promote G
i-dependent planar orientation of the mitotic spindle during asymmetric cell division | PDF (2,450 KB) - Drosophila Ric-8 regulates G
i cortical localization to promote G
i-dependent planar orientation of the mitotic spindle during asymmetric cell division | Supplementary information
See also: News and Views by Matsuzaki
Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins - pp1091 - 1098
Hongyan Wang, Kian Hong Ng, Hongliang Qian, David P. Siderovski, William Chia & Fengwei Yu
doi:10.1038/ncb1317
First Paragraph - | Full Text - Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins | PDF (1,757 KB) - Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins | Supplementary information
See also: News and Views by Matsuzaki
Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins - pp1099 - 1105
Bernhard Hampoelz, Oliver Hoeller, Sarah K. Bowman, Dara Dunican & Juergen A. Knoblich
doi:10.1038/ncb1318
First Paragraph - | Full Text - Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins | PDF (1,105 KB) - Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins | Supplementary information
See also: News and Views by Matsuzaki
Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability - pp1106 - 1112
Tohru Ishitani, Kunihiro Matsumoto, Ajay B. Chitnis & Motoyuki Itoh
doi:10.1038/ncb1311
First Paragraph - | Full Text - Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability | PDF (1,239 KB) - Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability | Supplementary information
Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation - pp1113 - 1117
Christopher Wynder, Mohamed-Ali Hakimi, Jonathan A. Epstein, Ali Shilatifard & Ramin Shiekhattar
doi:10.1038/ncb1312
First Paragraph - | Full Text - Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation | PDF (566 KB) - Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation | Supplementary information
Regulation of cholesterol and sphingomyelin metabolism by amyloid-
and presenilin - pp1118 - 1123
Marcus O. W. Grimm, Heike S. Grimm, Andreas J. Pätzold, Eva G. Zinser, Riikka Halonen, Marco Duering, Jakob-A. Tschäpe, Bart De Strooper, Ulrike Müller, Jie Shen & Tobias Hartmann
doi:10.1038/ncb1313
First Paragraph - | Full Text - Regulation of cholesterol and sphingomyelin metabolism by amyloid-
and presenilin | PDF (550 KB) - Regulation of cholesterol and sphingomyelin metabolism by amyloid-
and presenilin | Supplementary information
See also: News and Views by Mattson et al.
Phosphatidylinositol transfer protein-
in netrin-1-induced PLC signalling and neurite outgrowth - pp1124 - 1132
Yi Xie, Yu-Qiang Ding, Yan Hong, Zhu Feng, Sammy Navarre, Cai-Xia Xi, Xiao-Juan Zhu, Chun-Lei Wang, S. L. Ackerman, David Kozlowski, Lin Mei & Wen-Cheng Xiong
doi:10.1038/ncb1321
First Paragraph - | Full Text - Phosphatidylinositol transfer protein-
in netrin-1-induced PLC signalling and neurite outgrowth | PDF (1,341 KB) - Phosphatidylinositol transfer protein-
in netrin-1-induced PLC signalling and neurite outgrowth | Supplementary information
See also: News and Views by Mehlen & Bernet
Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function - pp1133 - 1139
Paul Chang, Margaret Coughlin & Timothy J. Mitchison
doi:10.1038/ncb1322
First Paragraph - | Full Text - Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function | PDF (1,965 KB) - Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function | Supplementary information
The Polo kinase Plk4 functions in centriole duplication - pp1140 - 1146
Robert Habedanck, York-Dieter Stierhof, Christopher J. Wilkinson & Erich A. Nigg
doi:10.1038/ncb1320
First Paragraph - | Full Text - The Polo kinase Plk4 functions in centriole duplication | PDF (1,010 KB) - The Polo kinase Plk4 functions in centriole duplication | Supplementary information


