Policy matters, policies that matter - p1037

doi:10.1038/ncb1105-1037a

Full Text - Policy matters, policies that matter | PDF (93 KB) - Policy matters, policies that matter

Reviewing peer review - p1037

doi:10.1038/ncb1105-1037b

Full Text - Reviewing peer review | PDF (94 KB) - Reviewing peer review

The cosmic surprise - p1038

Robert N. Eisenman reviews Vital Harmonies: Molecular Biology and our Shared Humanity by Erwin Fleissner

doi:10.1038/ncb1105-1038

Full Text - The cosmic surprise | PDF (94 KB) - The cosmic surprise

Prion domains: sequences, structures and interactions - pp1039 - 1044

Eric D. Ross, Allen Minton & Reed B. Wickner

doi:10.1038/ncb1105-1039

Abstract - | Full Text - Prion domains: sequences, structures and interactions | PDF (262 KB) - Prion domains: sequences, structures and interactions

Alzheimer peptides perturb lipid-regulating enzymes - pp1045 - 1047

Mark P. Mattson, Roy G. Cutler & Dong-Gyu Jo

doi:10.1038/ncb1105-1045

An increase in the size of the amyloid -peptide (A42 versus A40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the A42:A40 ratio may cause dysfunction and death of neurons.

Full Text - Alzheimer peptides perturb lipid-regulating enzymes | PDF (164 KB) - Alzheimer peptides perturb lipid-regulating enzymes

See also: Letter by Grimm et al.

Drosophila G-protein signalling: intricate roles for Ric-8? - pp1047 - 1049

Fumio Matsuzaki

doi:10.1038/ncb1105-1047

Receptor-independent G-protein signalling regulates both the orientation and position of the mitotic spindle during asymmetric cell division. Several new studies show that the targeting of G-protein subunits to the membrane requires Ric-8, pointing to possible novel roles for this protein in both receptor-dependent and -independent pathways.

Full Text - Drosophila G-protein signalling: intricate roles for Ric-8? | PDF (225 KB) - Drosophila G-protein signalling: intricate roles for Ric-8?

See also: Letter by David et al. | Letter by Wang et al. | Letter by Hampoelz et al.

A-kinase anchoring proteins: different partners, different dance - pp1050 - 1051

Lei Chen & Robert S. Kass

doi:10.1038/ncb1105-1050

How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.

Full Text - A-kinase anchoring proteins: different partners, different dance | PDF (238 KB) - A-kinase anchoring proteins: different partners, different dance

See also: Article by Hoshi et al.

Netrin PIPes up - pp1052 - 1053

Patrick Mehlen & Agnès Bernet

doi:10.1038/ncb1105-1052

Guidance molecules ensure that nerve cells grow in the correct direction during brain development. However, very little is known about the signals transmitted by these molecules. It now seems that netrin-1 — the first guidance molecule discovered — achieves this, in part, through activation of PITP, a protein involved in lipid transfer.

Full Text - Netrin PIPes up | PDF (139 KB) - Netrin PIPes up

See also: Letter by Xie et al.

Unleash the messenger - pp1054 - 1055

Asis K. Das & Gordon G. Carmichael

doi:10.1038/ncb1105-1054

A new paradigm for gene control has emerged — retaining mRNA in the nucleus to prevent its translation until the gene product is urgently needed.

Full Text - Unleash the messenger | PDF (177 KB) - Unleash the messenger

Autophagy: to die or not to die - p1056

Myrto Raftopoulou

doi:10.1038/ncb1105-1056

Full Text - Autophagy: to die or not to die | PDF (175 KB) - Autophagy: to die or not to die

Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal - pp1057 - 1065

Ranjan Swarup, Eric M. Kramer, Paula Perry, Kirsten Knox, H. M. Ottoline Leyser, Jim Haseloff, Gerrit T. S. Beemster, Rishikesh Bhalerao & Malcolm J. Bennett

doi:10.1038/ncb1316

Abstract - | Full Text - Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal | PDF (1,279 KB) - Root gravitropism requires lateral root cap and epidermal cells for transport and response to a mobile auxin signal | Supplementary information

Distinct enzyme combinations in AKAP signalling complexes permit functional diversity - pp1066 - 1073

Naoto Hoshi, Lorene K. Langeberg & John D. Scott

doi:10.1038/ncb1315

Abstract - | Full Text - Distinct enzyme combinations in AKAP signalling complexes permit functional diversity | PDF (1,418 KB) - Distinct enzyme combinations in AKAP signalling complexes permit functional diversity | Supplementary information

See also: News and Views by Chen & Kass

The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene - pp1074 - 1082

Benjamin D. Rowland, René Bernards & Daniel S. Peeper

doi:10.1038/ncb1314

Abstract - | Full Text - The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene | PDF (688 KB) - The KLF4 tumour suppressor is a transcriptional repressor of p53 that acts as a context-dependent oncogene | Supplementary information

Drosophila Ric-8 regulates Gi cortical localization to promote Gi-dependent planar orientation of the mitotic spindle during asymmetric cell division - pp1083 - 1090

Nicolas B. David, Charlotte A. Martin, Marion Segalen, François Rosenfeld, François Schweisguth & Yohanns Bellaïche

doi:10.1038/ncb1319

First Paragraph - | Full Text - Drosophila Ric-8 regulates Gi cortical localization to promote Gi-dependent planar orientation of the mitotic spindle during asymmetric cell division | PDF (2,450 KB) - Drosophila Ric-8 regulates Gi cortical localization to promote Gi-dependent planar orientation of the mitotic spindle during asymmetric cell division | Supplementary information

See also: News and Views by Matsuzaki

Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins - pp1091 - 1098

Hongyan Wang, Kian Hong Ng, Hongliang Qian, David P. Siderovski, William Chia & Fengwei Yu

doi:10.1038/ncb1317

First Paragraph - | Full Text - Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins | PDF (1,757 KB) - Ric-8 controls Drosophila neural progenitor asymmetric division by regulating heterotrimeric G proteins | Supplementary information

See also: News and Views by Matsuzaki

Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins - pp1099 - 1105

Bernhard Hampoelz, Oliver Hoeller, Sarah K. Bowman, Dara Dunican & Juergen A. Knoblich

doi:10.1038/ncb1318

First Paragraph - | Full Text - Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins | PDF (1,105 KB) - Drosophila Ric-8 is essential for plasma-membrane localization of heterotrimeric G proteins | Supplementary information

See also: News and Views by Matsuzaki

Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability - pp1106 - 1112

Tohru Ishitani, Kunihiro Matsumoto, Ajay B. Chitnis & Motoyuki Itoh

doi:10.1038/ncb1311

First Paragraph - | Full Text - Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability | PDF (1,239 KB) - Nrarp functions to modulate neural-crest-cell differentiation by regulating LEF1 protein stability | Supplementary information

Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation - pp1113 - 1117

Christopher Wynder, Mohamed-Ali Hakimi, Jonathan A. Epstein, Ali Shilatifard & Ramin Shiekhattar

doi:10.1038/ncb1312

First Paragraph - | Full Text - Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation | PDF (566 KB) - Recruitment of MLL by HMG-domain protein iBRAF promotes neural differentiation | Supplementary information

Regulation of cholesterol and sphingomyelin metabolism by amyloid- and presenilin - pp1118 - 1123

Marcus O. W. Grimm, Heike S. Grimm, Andreas J. Pätzold, Eva G. Zinser, Riikka Halonen, Marco Duering, Jakob-A. Tschäpe, Bart De Strooper, Ulrike Müller, Jie Shen & Tobias Hartmann

doi:10.1038/ncb1313

First Paragraph - | Full Text - Regulation of cholesterol and sphingomyelin metabolism by amyloid- and presenilin | PDF (550 KB) - Regulation of cholesterol and sphingomyelin metabolism by amyloid- and presenilin | Supplementary information

See also: News and Views by Mattson et al.

Phosphatidylinositol transfer protein- in netrin-1-induced PLC signalling and neurite outgrowth - pp1124 - 1132

Yi Xie, Yu-Qiang Ding, Yan Hong, Zhu Feng, Sammy Navarre, Cai-Xia Xi, Xiao-Juan Zhu, Chun-Lei Wang, S. L. Ackerman, David Kozlowski, Lin Mei & Wen-Cheng Xiong

doi:10.1038/ncb1321

First Paragraph - | Full Text - Phosphatidylinositol transfer protein- in netrin-1-induced PLC signalling and neurite outgrowth | PDF (1,341 KB) - Phosphatidylinositol transfer protein- in netrin-1-induced PLC signalling and neurite outgrowth | Supplementary information

See also: News and Views by Mehlen & Bernet

Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function - pp1133 - 1139

Paul Chang, Margaret Coughlin & Timothy J. Mitchison

doi:10.1038/ncb1322

First Paragraph - | Full Text - Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function | PDF (1,965 KB) - Tankyrase-1 polymerization of poly(ADP-ribose) is required for spindle structure and function | Supplementary information

The Polo kinase Plk4 functions in centriole duplication - pp1140 - 1146

Robert Habedanck, York-Dieter Stierhof, Christopher J. Wilkinson & Erich A. Nigg

doi:10.1038/ncb1320

First Paragraph - | Full Text - The Polo kinase Plk4 functions in centriole duplication | PDF (1,010 KB) - The Polo kinase Plk4 functions in centriole duplication | Supplementary information

Erratum
- p1147

doi:10.1038/ncb1323

Full Text - Erratum | PDF (168 KB) - Erratum