News and Views

Nature Cell Biology 7, 1052 - 1053 (2005)
doi:10.1038/ncb1105-1052

Netrin PIPes up

Patrick Mehlen1 & Agnès Bernet1

  1. Patrick Mehlen and Agnès Bernet are in the Apoptosis, Cancer and Development Laboratory, CNRS FRE2870, Centre Léon Bérard, 69008, Lyon, France. e-mail: mehlen@lyon.fnclcc.fr

Guidance molecules ensure that nerve cells grow in the correct direction during brain development. However, very little is known about the signals transmitted by these molecules. It now seems that netrin-1 — the first guidance molecule discovered — achieves this, in part, through activation of PITPalpha, a protein involved in lipid transfer.

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