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Nature Cell Biology 7, 1050 - 1051 (2005)
doi:10.1038/ncb1105-1050
A-kinase anchoring proteins: different partners, different dance
- Lei Chen and Robert S. Kass are in the Department of Pharmacology, Columbia University Medical Center, 630 W. 168th St., New York, NY 10032, USA e-mail: rsk20@columbia.edu
Abstract
How do cells achieve specific and efficient control over a wide spectrum of activities in the context of a limited protein repertoire? A possible answer comes from the recent demonstration that utilization of distinct enzymes by the same A-kinase anchoring protein (AKAP) depends on the AKAP-bound substrate, thus vastly increasing the diversity of AKAP-mediated protein regulation.
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