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Alzheimer peptides perturb lipid-regulating enzymes

Nature Cell Biology volume 7, pages 1045–1047 (2005)Cite this article

An increase in the size of the amyloid β-peptide (Aβ42 versus Aβ40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the Aβ42:Aβ40 ratio may cause dysfunction and death of neurons.

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Figure 1: Interactions between membrane–lipid metabolism, APP processing and Aβ neurotoxicity in AD.

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Authors and Affiliations

  1. the Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, 21224, MD, USA

    Mark P. Mattson, Roy G. Cutler & Dong-Gyu Jo

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  1. Mark P. Mattson
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  2. Roy G. Cutler
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  3. Dong-Gyu Jo
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Mattson, M., Cutler, R. & Jo, DG. Alzheimer peptides perturb lipid-regulating enzymes. Nat Cell Biol 7, 1045–1047 (2005). https://doi.org/10.1038/ncb1105-1045

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