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Nature Cell Biology 7, 1045 - 1047 (2005)
doi:10.1038/ncb1105-1045
Alzheimer peptides perturb lipid-regulating enzymes
Mark P. Mattson1, Roy G. Cutler1 & Dong-Gyu Jo1
- Mark P. Mattson, Roy G. Cutler and Dong-Gyu Jo are in the Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA. e-mail: mattsonm@grc.nia.nih.gov
Abstract
An increase in the size of the amyloid 
-peptide (A42 versus A40) may be a key factor in the pathogenesis of Alzheimer's disease. By altering the activities of enzymes involved in the metabolism of cholesterol and sphingomyelin, an increase in the A42:A40 ratio may cause dysfunction and death of neurons.
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