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Letter

Nature Cell Biology 7, 947–953 (1 October 2005) | doi:10.1038/ncb1307

The extracellular matrix guides the orientation of the cell division axis

Manuel Th|[eacute]|ry , Victor Racine , Anne P|[eacute]|pin , Matthieu Piel , Yong Chen , Jean-Baptiste Sibarita & Michel Bornens

The cell division axis determines the future positions of daughter cells and is therefore critical for cell fate. The positioning of the division axis has been mostly studied in systems such as embryos or yeasts, in which cell shape is well defined.