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Nature Cell Biology 7, 932 (1 October 2005) | doi:10.1038/ncb1005-932
Tumorigenesis: TCF4 feeds c-Jun
Abstract
Mutations in the canonical Wnt pathway proteins APC or β-catenin, which often result in constitutive activation of the transcription factor TCF4, are a frequent occurrence in colorectal cancers. Nateri et al. now report (Nature 437, 281; 2005) that canonical Wnt signalling joins forces with a non-canonical Wnt pathway — acting through JNK — to exacerbate Wnt's contribution to gut tumorigenesis.
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