Ethel Queralt and Frank Uhlmann are at the Cancer Research UK London Research Institute, Chromosome Segregation Laboratory, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. frank.uhlmann@cancer.org.uk
Anaphase onset is triggered when the protease separase cleaves the cohesive bond that holds replicated sister chromatids together until metaphase. In budding yeast, separase then also regulates mitotic exit. New findings suggest that in vertebrates, separase also participates in cell-cycle regulation, albeit in an unexpected manner.
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