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Letter

Nature Cell Biology 7, 86–92 (1 January 2005) | doi:10.1038/ncb1210

Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction

Sergey Apionishev , Natalya M. Katanayeva , Steven A. Marks , Daniel Kalderon & Andrew Tomlinson

The Hedgehog (Hh) signalling pathway is crucial for animal development and is aberrantly activated in several types of cancer. In Drosophila melanogaster, Hh signalling regulates target gene expression through the transcription factor Cubitus interruptus (Ci).