Access
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
Article
Nature Cell Biology 7, 30–41 (1 January 2005) | doi:10.1038/ncb1202
Akt and 14-3-3|[eta]| regulate Miz1 to control cell-cycle arrest after DNA damage
&
Abstract
The transcription factor Miz1 is required for DNA-damage-induced cell-cycle arrest. We have now identified 14-3-3|[eta]| as a gene that inhibits Miz1 function through interaction with its DNA binding domain. Binding of 14-3-3|[eta]| to Miz1 depends on phosphorylation by Akt and regulates the recovery of cells from arrest after DNA damage. Miz1 has two functions in response to DNA damage: first, it is required for upregulation of a large group of genes, a function that is regulated by c-Myc, but not by 14-3-3|[eta]|; second, Miz1 represses the expression of many genes in response to DNA damage in an Akt- and 14-3-3|[eta]|-regulated manner.
To read this article in full you may need to log in, make a payment or gain access through a site license (see right).
