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Nature Cell Biology 7, 14–16 (1 January 2005) | doi:10.1038/ncb0105-14

Hearing the messenger: Ins(1,4,5)P3 and deafness

Roberto Bruzzone & Martine Cohen-Salmon

The first genetic disease associated with connexin mutations was discovered about ten years ago, and since then eight more connexin genes have been implicated in human hereditary disorders affecting different organs. Despite all the information provided by animal models and by electrophysiological studies, a notable progress into understanding the sequence of events that occurs in connexin-based disorders has been lacking.