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Nature Cell Biology 7, 8 - 9 (2005)
doi:10.1038/ncb0105-8
A phosphatase for cofilin to be HAD
O'Neil Wiggan1, Barbara W. Bernstein1 & James R. Bamburg1
- O'Neil Wiggan, Barbara W. Bernstein and James R. Bamburg are in the Department of Biochemistry and Molecular Biology, Colorado State University, Fort Collins, CO 80523, USA. e-mail: jbamburg@lamar.colostate.edu
Abstract
Regulating actin dynamics through cofilin dephosphorylation is the role of a newly identified phosphatase, chronophin, a member of the haloacid dehalogenase (HAD) superfamily. Chronophin, the second cofilin phosphatase to be identified, has high phosphoprotein specificity towards cofilin, but curiously it was also discovered independently as a pyridoxal phosphate (vitamin B6) phosphatase.
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