News and Views

Nature Cell Biology 7, 14 - 16 (2005)
doi:10.1038/ncb0105-14

Hearing the messenger: Ins(1,4,5)P3 and deafness

Roberto Bruzzone1 & Martine Cohen-Salmon1

  1. Roberto Bruzzone and Martine Cohen-Salmon are in the Department of Neuroscience, Institut Pasteur, 75015 Paris, France. e-mail: bruzzone@pasteur.fr

Genetic studies have conclusively linked connexin channels to human diseases, but the nature of the signals that are disrupted by channel mutations has remained elusive. A recent study has taken advantage of a deafness-causing mutation to suggest that permeability to inositol trisphosphate, the Ca2+-mobilizing messenger, is crucial for normal hearing.

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