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Nature Cell Biology 6, 807–808 (1 September 2004) | doi:10.1038/ncb0904-807

Unravelling Ras signals in cardiovascular disease

Kenneth R. Chien & Masahiko Hoshijima

In the beginning there was Ras. For the past 30 years, studies of Ras signalling have laid a scientific foundation for molecular oncology, providing a rational basis for biologically targeted therapy for multiple forms of human cancers (for a review, see ref.