Table of contents


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Editorial

Germany's 'junior professor' fails to germinate p793

doi:10.1038/ncb0904-793


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Correspondence

Complex kinase requirements for EPEC pedestal formation p795

Alyson Swimm, Bettina Bommarius, Patrick Reeves, Melanie Sherman & Daniel Kalman

doi:10.1038/ncb0904-795a


Reply: Complex kinase requirements for EPEC pedestal formation pp795 - 796

Richard D. Hayward, Neil Phillips & Vassilis Koronakis

doi:10.1038/ncb0904-795b


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Book Reviews

Modifying germlines – or not? p797

Jane Maienschein reviews Designing our Descendents: The Promises and Perils of Genetic Modification by Audrey R. Chapman & Mark S. Frankel

doi:10.1038/ncb0904-797


Prion's progress p798

Neil R. Cashman reviews Prion Biology and Diseases, Second Edition by Stanley B. Prusiner

doi:10.1038/ncb0904-798


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Obituary

Francis Crick (8th June 1916 – 28th July 2004) pp799 - 800

Aaron Klug

doi:10.1038/ncb0904-799


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News and Views

A new checkpoint takes shape pp801 - 803

M. Andrew Hoyt

doi:10.1038/ncb0904-801

Cell duplication requires the coordination of nuclear division with diverse cellular morphogenesis events, such as cell wall growth. A novel checkpoint has been identified in yeast that coordinates these two events. Unexpectedly, the dynein-activating dynactin complex, but not dynein itself, is an essential component of this checkpoint mechanism.

See also: Article by Suzuki et al.


Stretching cell fate p803

Donald Mcdonald

doi:10.1038/ncb0904-803


An Apollon vista of death and destruction pp804 - 806

Seamus J. Martin

doi:10.1038/ncb0904-804

Proteins containing the BIR motif have been implicated as regulators of apoptosis and cell division. Apollon, an exceptionally large BIR-containing protein, inhibits apoptosis by targeting key cell death proteins for destruction by the ubiquitin-proteasome pathway. Now, deletion of apollon in the mouse has revealed a crucial function in cell division.

See also: Article by Hao et al.


Spindle checkpoint protein links Rb pathway to aneuploidy p806

Bernd Pulverer

doi:10.1038/ncb0904-806


Unravelling Ras signals in cardiovascular disease pp807 - 808

Kenneth R. Chien & Masahiko Hoshijima

doi:10.1038/ncb0904-807

The hyperplasia suppressor gene HSG, previously characterized for its function in mitochondrial fusion, has now been identified as a novel inhibitor of the Ras signalling pathway during smooth muscle cell proliferation. Because of the critical function of this process in atherosclerotic heart disease, these findings may have important clinical implications.

See also: Article by Chen et al.


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Perspective

Nuclear reprogramming: A key to stem cell function in regenerative medicine pp810 - 816

Jason Pomerantz & Helen M. Blau

doi:10.1038/ncb0904-810


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Cell of the Month

Cell of the month: Waves of glomerular podocytes p818

Carrie Phillips

doi:10.1038/ncb0904-818


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Articles

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration pp820 - 830

Ying Wen, Christina H. Eng, Jan Schmoranzer, Noemi Cabrera-Poch, Edward J. S. Morris, Michael Chen, Bradley J. Wallar, Arthur S. Alberts & Gregg G. Gundersen

doi:10.1038/ncb1160


Control of vesicle fusion by a tyrosine phosphatase pp831 - 839

Huong Huynh, Nunzio Bottini, Scott Williams, Vera Cherepanov, Lucia Musumeci, Kan Saito, Shane Bruckner, Eric Vachon, Xiaodong Wang, Joshua Kruger, Chung-Wai Chow, Maurizio Pellecchia, Edvard Monosov, Peter A. Greer, William Trimble, Gregory P. Downey & Tomas Mustelin

doi:10.1038/ncb1164


Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery pp840 - 848

Tamás Fischer, Susana Rodríguez-Navarro, Gislene Pereira, Attila Rácz, Elmar Schiebel & Ed Hurt

doi:10.1038/ncb1163


Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function pp849 - 860

Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda, Takashi Tsuruo & Mikihiko Naito

doi:10.1038/ncb1159

See also: News and Views by Martin


Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae pp861 - 871

Masaya Suzuki, Ryoji Igarashi, Mizuho Sekiya, Takahiko Utsugi, Shinichi Morishita, Masashi Yukawa & Yoshikazu Ohya

doi:10.1038/ncb1162

See also: News and Views by Hoyt


Dysregulation of HSG triggers vascular proliferative disorders pp872 - 883

Kuang-Hueih Chen, Xiaomei Guo, Dalong Ma, Yanhong Guo, Qian Li, Dongmei Yang, Pengfei Li, Xiaoyan Qiu, Shaojun Wen, Rui-Ping Xiao & Jian Tang

doi:10.1038/ncb1161

See also: News and Views by Chien & Hoshijima


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Letters

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase pp884 - 891

Alwin Krämer, Niels Mailand, Claudia Lukas, Randi G. Syljuåsen, Christopher J. Wilkinson, Erich A. Nigg, Jiri Bartek & Jiri Lukas

doi:10.1038/ncb1165


The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint pp892 - 898

Claire Acquaviva, Franz Herzog, Claudine Kraft & Jonathon Pines

doi:10.1038/ncb1167


Evidence for a size-sensing mechanism in animal cells pp899 - 905

Helmut Dolznig, Florian Grebien, Thomas Sauer, Hartmut Beug & Ernst W. Müllner

doi:10.1038/ncb1166


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Brief Communication

Homologue recognition during meiosis is associated with a change in chromatin conformation pp906 - 908

Pilar Prieto, Peter Shaw & Graham Moore

doi:10.1038/ncb1168


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