Germany's 'junior professor' fails to germinate - p793

doi:10.1038/ncb0904-793

Full Text - Germany's 'junior professor' fails to germinate | PDF (61 KB) - Germany's 'junior professor' fails to germinate

Complex kinase requirements for EPEC pedestal formation - p795

Alyson Swimm, Bettina Bommarius, Patrick Reeves, Melanie Sherman & Daniel Kalman

doi:10.1038/ncb0904-795a

Full Text - Complex kinase requirements for EPEC pedestal formation | PDF (85 KB) - Complex kinase requirements for EPEC pedestal formation

Reply: Complex kinase requirements for EPEC pedestal formation - pp795 - 796

Richard D. Hayward, Neil Phillips & Vassilis Koronakis

doi:10.1038/ncb0904-795b

Full Text - Reply: Complex kinase requirements for EPEC pedestal formation | PDF (85 KB) - Reply: Complex kinase requirements for EPEC pedestal formation

Modifying germlines – or not? - p797

Jane Maienschein reviews Designing our Descendents: The Promises and Perils of Genetic Modification by Audrey R. Chapman & Mark S. Frankel

doi:10.1038/ncb0904-797

Full Text - Modifying germlines – or not? | PDF (87 KB) - Modifying germlines – or not?

Prion's progress - p798

Neil R. Cashman reviews Prion Biology and Diseases, Second Edition by Stanley B. Prusiner

doi:10.1038/ncb0904-798

Full Text - Prion's progress | PDF (98 KB) - Prion's progress

Francis Crick (8th June 1916 – 28th July 2004) - pp799 - 800

Aaron Klug

doi:10.1038/ncb0904-799

Full Text - Francis Crick (8th June 1916 – 28th July 2004) | PDF (134 KB) - Francis Crick (8th June 1916 – 28th July 2004)

A new checkpoint takes shape - pp801 - 803

M. Andrew Hoyt

doi:10.1038/ncb0904-801

Cell duplication requires the coordination of nuclear division with diverse cellular morphogenesis events, such as cell wall growth. A novel checkpoint has been identified in yeast that coordinates these two events. Unexpectedly, the dynein-activating dynactin complex, but not dynein itself, is an essential component of this checkpoint mechanism.

Full Text - A new checkpoint takes shape | PDF (122 KB) - A new checkpoint takes shape

See also: Article by Suzuki et al.

Stretching cell fate - p803

Donald Mcdonald

doi:10.1038/ncb0904-803

Full Text - Stretching cell fate | PDF (86 KB) - Stretching cell fate

An Apollon vista of death and destruction - pp804 - 806

Seamus J. Martin

doi:10.1038/ncb0904-804

Proteins containing the BIR motif have been implicated as regulators of apoptosis and cell division. Apollon, an exceptionally large BIR-containing protein, inhibits apoptosis by targeting key cell death proteins for destruction by the ubiquitin-proteasome pathway. Now, deletion of apollon in the mouse has revealed a crucial function in cell division.

Full Text - An Apollon vista of death and destruction | PDF (161 KB) - An Apollon vista of death and destruction

See also: Article by Hao et al.

Spindle checkpoint protein links Rb pathway to aneuploidy - p806

Bernd Pulverer

doi:10.1038/ncb0904-806

Full Text - Spindle checkpoint protein links Rb pathway to aneuploidy | PDF (114 KB) - Spindle checkpoint protein links Rb pathway to aneuploidy

Unravelling Ras signals in cardiovascular disease - pp807 - 808

Kenneth R. Chien & Masahiko Hoshijima

doi:10.1038/ncb0904-807

The hyperplasia suppressor gene HSG, previously characterized for its function in mitochondrial fusion, has now been identified as a novel inhibitor of the Ras signalling pathway during smooth muscle cell proliferation. Because of the critical function of this process in atherosclerotic heart disease, these findings may have important clinical implications.

Full Text - Unravelling Ras signals in cardiovascular disease | PDF (106 KB) - Unravelling Ras signals in cardiovascular disease

See also: Article by Chen et al.

Nuclear reprogramming: A key to stem cell function in regenerative medicine - pp810 - 816

Jason Pomerantz & Helen M. Blau

doi:10.1038/ncb0904-810

Abstract - | Full Text - Nuclear reprogramming: A key to stem cell function in regenerative medicine | PDF (373 KB) - Nuclear reprogramming: A key to stem cell function in regenerative medicine

Cell of the month: Waves of glomerular podocytes - p818

Carrie Phillips

doi:10.1038/ncb0904-818

Full Text - Cell of the month: Waves of glomerular podocytes | PDF (347 KB) - Cell of the month: Waves of glomerular podocytes

EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration - pp820 - 830

Ying Wen, Christina H. Eng, Jan Schmoranzer, Noemi Cabrera-Poch, Edward J. S. Morris, Michael Chen, Bradley J. Wallar, Arthur S. Alberts & Gregg G. Gundersen

doi:10.1038/ncb1160

Abstract - | Full Text - EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration | PDF (529 KB) - EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration

Control of vesicle fusion by a tyrosine phosphatase - pp831 - 839

Huong Huynh, Nunzio Bottini, Scott Williams, Vera Cherepanov, Lucia Musumeci, Kan Saito, Shane Bruckner, Eric Vachon, Xiaodong Wang, Joshua Kruger, Chung-Wai Chow, Maurizio Pellecchia, Edvard Monosov, Peter A. Greer, William Trimble, Gregory P. Downey & Tomas Mustelin

doi:10.1038/ncb1164

Abstract - | Full Text - Control of vesicle fusion by a tyrosine phosphatase | PDF (1,809 KB) - Control of vesicle fusion by a tyrosine phosphatase | Supplementary information

Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery - pp840 - 848

Tamás Fischer, Susana Rodríguez-Navarro, Gislene Pereira, Attila Rácz, Elmar Schiebel & Ed Hurt

doi:10.1038/ncb1163

Abstract - | Full Text - Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery | PDF (1,041 KB) - Yeast centrin Cdc31 is linked to the nuclear mRNA export machinery | Supplementary information

Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function - pp849 - 860

Yanyan Hao, Keiko Sekine, Atsushi Kawabata, Hitoshi Nakamura, Toshiyasu Ishioka, Hirokazu Ohata, Ryohei Katayama, Chizuko Hashimoto, Xiaodong Zhang, Tetsuo Noda, Takashi Tsuruo & Mikihiko Naito

doi:10.1038/ncb1159

Abstract - | Full Text - Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function | PDF (464 KB) - Apollon ubiquitinates SMAC and caspase-9, and has an essential cytoprotection function

See also: News and Views by Martin

Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae - pp861 - 871

Masaya Suzuki, Ryoji Igarashi, Mizuho Sekiya, Takahiko Utsugi, Shinichi Morishita, Masashi Yukawa & Yoshikazu Ohya

doi:10.1038/ncb1162

Abstract - | Full Text - Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae | PDF (444 KB) - Dynactin is involved in a checkpoint to monitor cell wall synthesis in Saccharomyces cerevisiae | Supplementary information

See also: News and Views by Hoyt

Dysregulation of HSG triggers vascular proliferative disorders - pp872 - 883

Kuang-Hueih Chen, Xiaomei Guo, Dalong Ma, Yanhong Guo, Qian Li, Dongmei Yang, Pengfei Li, Xiaoyan Qiu, Shaojun Wen, Rui-Ping Xiao & Jian Tang

doi:10.1038/ncb1161

Abstract - | Full Text - Dysregulation of HSG triggers vascular proliferative disorders | PDF (1,525 KB) - Dysregulation of HSG triggers vascular proliferative disorders | Supplementary information

See also: News and Views by Chien & Hoshijima

Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase - pp884 - 891

Alwin Krämer, Niels Mailand, Claudia Lukas, Randi G. Syljuåsen, Christopher J. Wilkinson, Erich A. Nigg, Jiri Bartek & Jiri Lukas

doi:10.1038/ncb1165

First Paragraph - | Full Text - Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase | PDF (1,434 KB) - Centrosome-associated Chk1 prevents premature activation of cyclin-B–Cdk1 kinase | Supplementary information

The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint - pp892 - 898

Claire Acquaviva, Franz Herzog, Claudine Kraft & Jonathon Pines

doi:10.1038/ncb1167

First Paragraph - | Full Text - The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint | PDF (1,565 KB) - The anaphase promoting complex/cyclosome is recruited to centromeres by the spindle assembly checkpoint | Supplementary information

Evidence for a size-sensing mechanism in animal cells - pp899 - 905

Helmut Dolznig, Florian Grebien, Thomas Sauer, Hartmut Beug & Ernst W. Müllner

doi:10.1038/ncb1166

First Paragraph - | Full Text - Evidence for a size-sensing mechanism in animal cells | PDF (1,758 KB) - Evidence for a size-sensing mechanism in animal cells | Supplementary information

Homologue recognition during meiosis is associated with a change in chromatin conformation - pp906 - 908

Pilar Prieto, Peter Shaw & Graham Moore

doi:10.1038/ncb1168

Abstract - | Full Text - Homologue recognition during meiosis is associated with a change in chromatin conformation | PDF (415 KB) - Homologue recognition during meiosis is associated with a change in chromatin conformation | Supplementary information